Toutes les publications de l'quipe du Dr Antonny
92   Kovcs D., Gay A.S., Debayle D., Ablanet S., Patel A., Mesmin B., Luton F. and Antonny B. (2024). Lipid exchange at ER-trans-Golgi contact sites governs polarized cargo sorting. J Cell Biol, 223 (1) :

91   Jzquel G., Rampal C., Guimard C., Kovacs D., Polidori J., Bigay J., Bignon J., Askenatzis L., Litaudon M., Pham V.C., Huong DT.M., Nguyen A.L., Pruvost A., Virolle T., Mesmin B., Desrat S., Antonny B. and Roussi F. (2023). Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein. J Med Chem, 66 (20) : 14208-14220

90   Harayama T. and Antonny B. (2023). Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function. Cold Spring Harb Perspect Biol, 15 (7) :

89   Subra M., Antonny B. and Mesmin B. (2023). New insights into the OSBP‒VAP cycle. Curr Opin Cell Biol, 82 () : 102172

88   Subra M., Dezi M., Bigay J., Lacas-Gervais S., Di Cicco A., Arajo AR.D., Ablanet S., Fleuriot L., Debayle D., Gautier R., Patel A., Roussi F., Antonny B., Lvy D. and Mesmin B. (2023). VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites. Dev Cell, 58 (2) : 121-138.e9

87   Reynaud A., Magdeleine M., Patel A., Gay A.S., Debayle D., Abelanet S. and Antonny B. (2022). Tumor protein D54 binds intracellular nanovesicles via an extended amphipathic region. J Biol Chem, () : 102136

86   Jamecna D. and Antonny B. (2021). Intrinsically disordered protein regions at membrane contact sites. Biochim Biophys Acta Mol Cell Biol Lipids, 1866 (11) : 159020

85   de la Mora E., Dezi M., Di Cicco A., Bigay J., Gautier R., Manzi J., Polidori J., Castao-Dez D., Mesmin B., Antonny B. and Lvy D. (2021). Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites. Nat Commun, 12 (1) : 3459

84   Gimnez-Andrs M., Emerič, T., Antoine-Bally S., D'Ambrosio J.M., Antonny B., Derganc J., Č,opič and A. (2021). Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly. Elife, 10 () :

83   Miserey-Lenkei S., Trajkovic K., D'Ambrosio J.M., Patel A.J., Č,opič, A., Mathur P., Schauer K., Goud B., Albanse V., Gautier R., Subra M., Kovacs D., Barelli H. and Antonny B. (2021). A comprehensive library of fluorescent constructs of SARS-CoV-2 proteins and their initial characterisation in different cell types. Biol Cell, 113 (7) : 311-328

82   Bigay J., Mesmin B. and Antonny B. (2020). [A lipid exchange market : vectorial cholesterol transport by the protein OSBP]. Med Sci (Paris), 36 (2) : 130-136

81   Peresse T., Kovacs D., Subra M., Bigay J., Tsai M.C., Polidori J., Gautier R., Desrat S., Fleuriot L., Debayle D., Litaudon M., Pham V.C., Bignon J., Antonny B., Roussi F. and Mesmin B. (2020). Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor. J Biol Chem, () :

80   Tiberti M.L., Antonny B. and Gautier R. (2020). The transbilayer distribution of polyunsaturated phospholipids determines their facilitating effect on membrane deformation. Soft Matter, () :

79   Arita M. and Bigay J. (2019). Poliovirus Evolution toward Independence from the Phosphatidylinositol-4 Kinase III beta/Oxysterol-Binding Protein Family I Pathway. ACS Infect Dis, () :

78   Jamecna D., Polidori J., Mesmin B., Dezi M., Levy D., Bigay J. and Antonny B. (2019). An Intrinsically Disordered Region in OSBP Acts as an Entropic Barrier to Control Protein Dynamics and Orientation at Membrane Contact Sites. Dev Cell, () :

77   Mesmin B., Kovacs D. and D'Angelo G. (2019). Lipid exchange and signaling at ER-Golgi contact sites. Curr Opin Cell Biol, 57 () : 8-15

76   Gautier R., Bacle A., Tiberti M.L., Fuchs P.F., Vanni S. and Antonny B. (2018). PackMem: A Versatile Tool to Compute and Visualize Interfacial Packing Defects in Lipid Bilayers. Biophys J, 115 (3) : 436-444

75   Antonny B., Bigay J. and Mesmin B. (2018). The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol. Annu Rev Biochem, 87 () : 809-837

74   Manni M.M., Tiberti M.L., Pagnotta S., Barelli H., Gautier R. and Antonny B. (2018). Acyl chain asymmetry and polyunsaturation of brain phospholipids facilitate membrane vesiculation without leakage. Elife, 7 () :

73   Mesmin B., Bigay J., Polidori J., Jamecna D., Lacas-Gervais S. and Antonny B. (2017). Sterol transfer, PI4P consumption, and control of membrane lipid order by endogenous OSBP. EMBO J, () :

72   Albulescu L., Bigay J., Biswas B., Weber-Boyvat M., Dorobantu C.M., Delang L., van der Schaar H.M., Jung Y.S., Neyts J., Olkkonen V.M., van Kuppeveld FJ.M. and Strating JRP.M. (2017). Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res, 140 () : 37-44

71   Magdeleine M., Gautier R., Gounon P., Barelli H., Vanni S. and Antonny B. (2016). A filter at the entrance of the Golgi that selects vesicles according to size and bulk lipid composition. Elife, 5 () :

70   Ferru-Clement R., Spanova M., Dhayal S., Morgan N.G., Helye R., Becq F., Hirose H., Antonny B., Vamparys L., Fuchs P.F. and Ferreira T. (2016). Targeting surface voids to counter membrane disorders in lipointoxication-related diseases. J Cell Sci, 129 (12) : 2368-81

69   Barelli H. and Antonny B. (2016). Lipid unsaturation and organelle dynamics. Curr Opin Cell Biol, 41 () : 25-32

68   Mesmin B. and Antonny B. (2016). The counterflow transport of sterols and PI4P. Biochim Biophys Acta, 1861 (8 Pt B) : 940-51

67   Doucet C.M., Esmery N., de Saint-Jean M. and Antonny B. (2015). Membrane Curvature Sensing by Amphipathic Helices Is Modulated by the Surrounding Protein Backbone. PLoS One, 10 (9) : e0137965

66   Moser von Filseck J., Copic A., Delfosse V., Vanni S., Jackson C.L., Bourguet W. and Drin G. (2015). INTRACELLULAR TRANSPORT. Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate. Science, 349 (6246) : 432-6

65   Antonny B., Vanni S., Shindou H. and Ferreira T. (2015). From zero to six double bonds: phospholipid unsaturation and organelle function. Trends Cell Biol, 25 (7) : 427-36

64   von Filseck J.M., Vanni S., Mesmin B., Antonny B. and Drin G. (2015). A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. Nat Commun, 6 () : 6671

63   Garten M., Prevost C., Cadart C., Gautier R., Bousset L., Melki R., Bassereau P. and Vanni S. (2015). Methyl-branched lipids promote the membrane adsorption of alpha-synuclein by enhancing shallow lipid-packing defects. Phys Chem Chem Phys, 17 (24) : 15589-97

62   Strating J.R., van der Linden L., Albulescu L., Bigay J., Arita M., Delang L., Leyssen P., van der Schaar H.M., Lanke K.H., Thibaut H.J., Ulferts R., Drin G., Schlinck N., Wubbolts R.W., Sever N., Head S.A., Liu J.O., Beachy P.A., De Matteis M.A., Shair M.D., Olkkonen V.M., Neyts J. and van Kuppeveld F.J. (2015). Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep, 10 (4) : 600-15

61   Horchani H., de Saint-Jean M., Barelli H. and Antonny B. (2014). Interaction of the Spo20 Membrane-Sensor Motif with Phosphatidic Acid and Other Anionic Lipids, and Influence of the Membrane Environment. PLoS One, 9 (11) : e113484

60   Vanni S., Hirose H., Barelli H., Antonny B. and Gautier R. (2014). A sub-nanometre view of how membrane curvature and composition modulate lipid packing and protein recruitment. Nat Commun, 5 () : 4916

59   Pinot M., Vanni S., Pagnotta S., Lacas-Gervais S., Payet L.A., Ferreira T., Gautier R., Goud B., Antonny B. and Barelli H. (2014). Lipid cell biology. Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins. Science, 345 (6197) : 693-7

58   Candat A., Paszkiewicz G., Neveu M., Gautier R., Logan D.C., Avelange-Macherel M.H. and Macherel D. (2014). The ubiquitous distribution of late embryogenesis abundant proteins across cell compartments in Arabidopsis offers tailored protection against abiotic stress. Plant Cell, 26 (7) : 3148-66

57   Habbal A., Barelli H. and Malandain G. (2014). Assessing the ability of the 2D Fisher-KPP equation to model cell-sheet wound closure. Math Biosci, 252 () : 45-59

56   Drin G. (2014). Topological regulation of lipid balance in cells. Annu Rev Biochem, 83 () : 51-77

55   Antonny B., Audhya J., l Bagnat M., von Blume J., Briggs J.A., Giraudo C., Kaeser P.S., Miller E., Reinisch K., Sbalzarini I.F., Schuldiner M., Shen J., Takamori S., Verstreken P. and Walther T. (2013). Directing traffic into the future. Dev Cell, 27 (5) : 480-4

54   Folly-Klan M., Alix E., Stalder D., Ray P., Duarte L.V., Delprato A., Zeghouf M., Antonny B., Campanacci V., Roy C.R. and Cherfils J. (2013). A novel membrane sensor controls the localization and ArfGEF activity of bacterial RalF. PLoS Pathog, 9 (11) : e1003747

53   Mesmin B., Bigay J., Moser von Filseck J., Lacas-Gervais S., Drin G. and Antonny B. (2013). A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP. Cell, 155 (4) : 830-43

52   Derganc J., Antonny B. and Copic A. (2013). Membrane bending: the power of protein imbalance. Trends Biochem Sci, 38 (11) : 576-84

51   Payet L.A., Pineau L., Snyder E.C., Colas J., Moussa A., Vannier B., Bigay J., Clarhaut J., Becq F., Berjeaud J.M., Vandebrouck C. and Ferreira T. (2013). Saturated fatty acids alter the late secretory pathway by modulating membrane properties. Traffic, 14 (12) : 1228-41

50   Thiam A.R., Antonny B., Wang J., Delacotte J., Wilfling F., Walther T.C., Beck R., Rothman J.E. and Pincet F. (2013). COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function. Proc Natl Acad Sci U S A, () :

49   Mesmin B. and Antonny B. (2013). Cell biology. Vitamin currency in a lipid exchange market. Science, 340 (6136) : 1051-2

48   Stalder D. and Antonny B. (2013). Arf GTPase regulation through cascade mechanisms and positive feedback loops. FEBS Lett, 587 (13) : 2028-35

47   Ambroggio E.E., Sillibourne J., Antonny B., Manneville J.B. and Goud B. (2013). Arf1 and membrane curvature cooperate to recruit Arfaptin2 to liposomes. PLoS One, 8 (4) : e62963

46   Vamparys L., Gautier R., Vanni S., Bennett W.F., Tieleman D.P., Antonny B., Etchebest C. and Fuchs P.F. (2013). Conical Lipids in Flat Bilayers Induce Packing Defects Similar to that Induced by Positive Curvature. Biophys J, 104 (3) : 585-93

45   Vanni S., Vamparys L., Gautier R., Drin G., Etchebest C., Fuchs P.F. and Antonny B. (2013). Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues. Biophys J, 104 (3) : 575-84

44   Mesmin B., Antonny B. and Drin G. (2013). Insights into the mechanisms of sterol transport between organelles. Cell Mol Life Sci, 70 (18) : 3405-21

43   Bigay J. and Antonny B. (2012). Curvature, lipid packing, and electrostatics of membrane organelles: defining cellular territories in determining specificity. Dev Cell, 23 (5) : 886-95

42   Manneville J.B., Leduc C., Sorre B. and Drin G. (2012). Studying in vitro membrane curvature recognition by proteins and its role in vesicular trafficking. Methods Cell Biol, 108 () : 47-71

41   de Saint-Jean M., Delfosse V., Douguet D., Chicanne G., Payrastre B., Bourguet W., Antonny B. and Drin G. (2011). Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J Cell Biol, 195 (6) : 965-78

40   Pranke I.M., Morello V., Bigay J., Gibson K., Verbavatz J.M., Antonny B. and Jackson C.L. (2011). alpha-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding. J Cell Biol, 194 (1) : 89-103

39   Gonzalez-Rubio P., Gautier R., Etchebest C. and Fuchs P.F. (2011). Amphipathic-Lipid-Packing-Sensor interactions with lipids assessed by atomistic molecular dynamics. Biochim Biophys Acta, 1808 (9) : 2119-27

38   Antonny B. (2011). Mechanisms of membrane curvature sensing. Annu Rev Biochem, 80 () : 101-23

37   Stalder D., Barelli H., Gautier R., Macia E., Jackson C.L. and Antonny B. (2011). Kinetic studies of the arf activator arno on model membranes in the presence of arf effectors suggest control by a positive feedback loop. J Biol Chem, 286 (5) : 3873-83

36   Ambroggio E., Sorre B., Bassereau P., Goud B., Manneville J.B. and Antonny B. (2010). ArfGAP1 generates an Arf1 gradient on continuous lipid membranes displaying flat EMBO J, 29 (2) : 292-303

35   Drin G., Bigay J. and Antonny B. (2009). [Regulation of vesicular transport by membrane curvature] Med Sci (Paris), 25 (5) : 483-8

34   Barelli H. and Antonny B. (2009). Cell biology: Detached membrane bending. Nature, 458 (7235) : 159

33   Chabre M., Deterre P. and Antonny B. (2009). The apparent cooperativity of some GPCRs does not necessarily imply dimerization. Trends Pharmacol Sci, () :

32   Roux A. and Antonny B. (2008). The long and short of membrane fission. Cell, 135 (7) : 1163-5

31   Kliouchnikov L., Bigay J., Mesmin B., Parnis A., Rawet M., Goldfeder N., Antonny B. and Cassel D. (2009). Discrete determinants in ArfGAP2/3 conferring Golgi localization and regulation by the COPI coat. Mol Biol Cell, 20 (3) : 859

30   Manneville J.B., Casella J.F., Ambroggio E., Gounon P., Bertherat J., Bassereau P., Cartaud J., Antonny B. and Goud B. (2008). COPI coat assembly occurs on liquid-disordered domains and the associated membrane deformations are limited by membrane tension. Proc Natl Acad Sci U S A, 105 (44) : 16946

29   Gautier R., Douguet D., Antonny B. and Drin G. (2008). HELIQUEST: a web server to screen sequences with specific {alpha} -helical properties. Bioinformatics, 24 (18) : 2101-2

28   Drin G., Morello V., Casella J.F., Gounon P. and Antonny B. (2008). Asymmetric tethering of flat and curved lipid membranes by a golgin. Science, 320 (5876) : 670-3

27   Viaud J., Zeghouf M., Barelli H., Zeeh J.V., Padilla A., Guibert B., Chardin P., Royer C.A., Cherfils J. and Chavanieu A. (2007). Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes Proc Natl Acad Sci USA, 104 (25) : 10370-5

26   Mesmin B., Drin G., Levi S., Rawet M., Cassel D., Bigay J. and Antonny B. (2007). Two Lipid-Packing Sensor Motifs Contribute to the Sensitivity of ArfGAP1 to membrane curvature. Biochemistry, 46 (7) : 1779-90

25   Drin G., Casella J.F., Gautier R., Boehmer T., Schwartz T.U. and Antonny B. (2007). A general amphipathic alpha-helical motif for sensing membrane curvature. Nat Struct Mol Biol, 14 (2) : 138-46

24   Antonny B. and (2006). Membrane deformation by protein coats. Curr Opin Cell Biol, 18 (4) : 386-94

23   Mesmin B. and Antonny B. (2006). GEF and Glucosylation Assays on Liposome-Bound Rac. Methods Enzymol, 406 () : 70-80

22   Bigay J. and Antonny B. (2005). Real-time assays for the assembly-disassembly cycle of COP coats on Methods Enzymol, 404 () : 95-107

21   Antonny B., Bigay J., Casella J.F., Drin G., Mesmin B. and Gounon P. (2005). Membrane curvature and the control of GTP hydrolysis in Arf1 during COPI vesicle formation. Biochem Soc Trans, 33 (Pt 4) : 619-22

20   Chabre M. and le Maire M. (2005). Monomeric G-protein-coupled receptor as a functional unit. Biochemistry, 44 (27) : 9395-403

19   Bigay J., Casella J.F., Drin G., Mesmin B. and Antonny B. (2005). ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif EMBO J, 24 (13) : 2244-53

18   Antonny B. (2004). SNARE filtering by dynamin. Cell, 119 (5) : 581-2

17   Mesmin B., Robbe K., Geny B., Luton F., Brandolin G., Popoff M.R. and Antonny B. (2004). A phosphatidylserine-binding site in the cytosolic fragment of C Sordellii Lethal Toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity. J Biol Chem, 279 (48) : 49876-82

16   Bigay J., Gounon P., Robineau S. and Antonny B. (2003). Lipid packing sensed by ArfGAP1 couples COPI coat disassembly to membrane curvature. Nature, 426 (6966) : 563-6

15   Robbe K. and Antonny B. (2003). Liposomes in the study of GDP/GTP cycle of Arf and related small G proteins. Methods Enzymol, 372 () : 151-66

14   Chabre M., Cone R. and Saibil H. (2003). Biophysics: is rhodopsin dimeric in native retinal rods? Nature, 426 (6962) : 30-1; discussion 31

13   Antonny B., Gounon P., Schekman R. and Orci L. (2003). Self-assembly of minimal COPII cages. EMBO Rep, 4 (4) : 419-24

12   Cherfils J. and Chabre M. (2003). Activation of G-protein Galpha subunits by receptors through Galpha-Gbeta Trends Biochem Sci, 28 (1) : 13-7

11   Robbe K., Otto-Bruc A., Chardin P. and Antonny B. (2003). Dissociation of GDI and membrane translocation are required for efficient activation of Rac by the DH-PH region of Tiam1. J Biol Chem, 278 (7) : 4756-62

10   Antonny B. and Schekman R. (2001). ER export: public transportation by the COPII coach. Curr Opin Cell Biol, 13 (4) : 438-43

9   Antonny B., Madden D., Hamamoto S., Orci L. and Schekman R. (2001). Dynamics of the COPII coat with GTP and stable analogues. Nat Cell Biol, 3 (6) : 531-7

8   Robineau S., Chabre M. and Antonny B. (2000). Binding site of brefeldin A at the interface between the small G protein ARF1 and the nucleotide-exchnage factor Sec7 domain. Proc Natl Acad Sci U S A, 97 (18) : 9913-8

7   Beraud-Dufour S., Paris S., Chabre M. and Antonny B. (1999). Dual interaction of ADP ribosylation factor 1 with Sec7 domain and with lipid membranes during catalysis of guanine nucleotide exchange. J Biol Chem, 274 (53) : 37629-36

6   Peyroche A., Antonny B., Robineau S., Acker J., Cherfils J. and Jackson C.L. (1999). Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain. Mol Cell, 3 (3) : 275-85

5   Beraud-Dufour S., Robineau S., Chardin P., Paris S., Chabre M., Cherfils J. and Antonny B. (1998). A glutamic finger in the guanine nucleotide exchange factor ARNO displaces Mg2+ and the beta-phosphate to destabilize GDP on Arf1. EMBO J, 17 (13) : 3651-9

4   Chabre M., Antonny B. and Paris S. (1998). PIP2: activator ... or terminator of small G proteins? Trends Biochem Sci, 23 (3) : 98-100

3   Antonny B., Huber I., Paris S., Chabre M. and Cassel D. (1997). Activation of ADP-ribosylation factor 1 GTPase-activating protein by J Biol Chem, 272 (49) : 30848-51

2   Paris S., Beraud-Dufour S., Robineau S., Bigay J., Antonny B., Chabre M. and Chardin P. (1997). Role of protein-phospholipid interactions in the activation of ARF1 by the guanine nucleotide exchnage factor Arno. J Biol Chem, 272 (35) : 22221-6

1   Antonny B., Beraud-Dufour S., Chardin P. and Chabre M. (1997). N-terminal hydrophobic residues of the G-protein ADP-ribosylation factor-1 insert into membrane phospholipids upon GDP to GTP exchange. Biochemistry, 36 (15) : 4675-84