Toutes les publications de l'quipe du Dr Lesage
136   Choveau F.S., Ben Soussia I., Bichet D., Franck C.C., Feliciangeli S. and Lesage F. (2021). Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels. Front Pharmacol, 12 () : 755826

135   Khoubza L., Chatelain F.C., Feliciangeli S., Lesage F. and Bichet D. (2021). Physiological roles of heteromerization: focus on the two-pore domain potassium channels. J Physiol, 599 (4) : 1041-1055

134   Busserolles J., Ben Soussia I., Pouchol L., Marie N., Meleine M., Devilliers M., Judon C., Schopp J., Clé,menceau L., Poupon L., Chapuy E., Richard S., Noble F., Lesage F., Ducki S., Eschalier A. and Lolignier S. (2020). TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects. Br J Pharmacol, 177 (20) : 4782-4795

133   Cooper A., Butto T., Hammer N., Jagannath S., Fend-Guella D.L., Akhtar J., Radyushkin K., Lesage F., Winter J., Strand S., Roeper J., Zechner U. and Schweiger S. (2020). Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nat Commun, 11 (1) : 480

132   Nematian-Ardestani E., Abd-Wahab F., Chatelain F.C., Sun H., Schewe M., Baukrowitz T. and Tucker S.J. (2020). Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K(+) channel. J Biol Chem, 295 (2) : 610-618

131   Ben Soussia I., El Mouridi S., Kang D., Leclercq-Blondel A., Khoubza L., Tardy P., Zariohi N., Gendrel M., Lesage F., Kim E.J., Bichet D., Andrini O. and Boulin T. (2019). Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels. Nat Commun, 10 (1) : 787

130   Royal P., Andres-Bilbe A., Á,valos Prado P., Verkest C., Wdziekonski B., Schaub S., Baron A., Lesage F., Gasull X., Levitz J. and Sandoz G. (2019). Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron, 101 (2) : 232-245.e6

129   Soussia I.B., Choveau F.S., Blin S., Kim E.J., Feliciangeli S., Chatelain F.C., Kang D., Bichet D. and Lesage F. (2018). Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels. Front Mol Neurosci, 11 () : 301

128   Inoue M., Matsuoka H., Lesage F. and Harada K. (2019). Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells. FASEB J, 33 (1) : 455-468

127   Schwingshackl A., Lopez B., Teng B., Luellen C., Lesage F., Belperio J., Olcese R. and Waters C.M. (2017). Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol, 313 (6) : L1030-L1046

126   Buehler P.K., Bleiler D., Tegtmeier I., Heitzmann D., Both C., Georgieff M., Lesage F., Warth R. and Thomas J. (2017). Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice. Respir Physiol Neurobiol, 244 () : 17-25

125   Bobak N., Feliciangeli S., Chen C.C., Ben Soussia I., Bittner S., Pagnotta S., Ruck T., Biel M., Wahl-Schott C., Grimm C., Meuth S.G. and Lesage F. (2017). Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels. Sci Rep, 7 (1) : 649

124   Vivier D., Soussia I.B., Rodrigues N., Lolignier S., Devilliers M., Chatelain F.C., Prival L., Chapuy E., Bourdier G., Bennis K., Lesage F., Eschalier A., Busserolles J. and Ducki S. (2017). Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity. J Med Chem, 60 (3) : 1076-1088

123   Christensen A.H., Chatelain F.C., Huttner I.G., Olesen M.S., Soka M., Feliciangeli S., Horvat C., Santiago C.F., Vandenberg J.I., Schmitt N., Olesen S.P., Lesage F. and Fatkin D. (2016). The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. J Mol Cell Cardiol, 97 () : 24-35

122   Ronjat M., Feng W., Dardevet L., Dong Y., Al Khoury S., Chatelain F.C., Vialla V., Chahboun S., Lesage F., Darbon H., Pessah I.N. and De Waard M. (2016). In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci U S A, 113 (17) : E2460-8

121   Blin S., Ben Soussia I., Kim E.J., Brau F., Kang D., Lesage F. and Bichet D. (2016). Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties. Proc Natl Acad Sci U S A, 113 (15) : 4200-5

120   Vivier D., Bennis K., Lesage F. and Ducki S. (2016). Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem, 59 (11) : 5149-57

119   Feliciangeli S., Chatelain F.C., Bichet D. and Lesage F. (2015). The family of K2P channels: salient structural and functional properties. J Physiol, 593 (12) : 2587-603

118   Bichet D., Blin S., Feliciangeli S., Chatelain F.C., Bobak N. and Lesage F. (2015). Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2. Pflugers Arch, 467 (5) : 1121-31

117   Pereira V., Busserolles J., Christin M., Devilliers M., Poupon L., Legha W., Alloui A., Aissouni Y., Bourinet E., Lesage F., Eschalier A., Lazdunski M. and Noel J. (2014). Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Pain, 155 (12) : 2534-44

116   Comoglio Y., Levitz J., Kienzler M.A., Lesage F., Isacoff E.Y. and Sandoz G. (2014). Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proc Natl Acad Sci U S A, 111 (37) : 13547-52

115   Blin S., Chatelain F.C., Feliciangeli S., Kang D., Lesage F. and Bichet D. (2014). Tandem Pore Domain Halothane-inhibited K+ Channel Subunits THIK1 and THIK2 Assemble and Form Active Channels. J Biol Chem, 289 (41) : 28202-12

114   Bagriantsev S.N., Chatelain F.C., Clark K.A., Alagem N., Reuveny E. and Minor DL J.r. (2014). Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. ACS Chem Neurosci, 5 (9) : 812-22

113   Chen H., Chatelain F.C. and Lesage F. (2014). Altered and dynamic ion selectivity of K+ channels in cell development and excitability. Trends Pharmacol Sci, 35 (9) : 461-9

112   Xiao Z., Cilz N.I., Kurada L., Hu B., Yang C., Wada E., Combs C.K., Porter J.E., Lesage F. and Lei S. (2014). Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model. J Neurosci, 34 (20) : 7027-42

111   Rodrigues N., Bennis K., Vivier D., Pereira V., C Chatelain F., Chapuy E., Deokar H., Busserolles J., Lesage F., Eschalier A. and Ducki S. (2014). Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel. Eur J Med Chem, 75 () : 391-402

110   Wang W., Putra A., Schools G.P., Ma B., Chen H., Kaczmarek L.K., Barhanin J., Lesage F. and Zhou M. (2013). The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Front Cell Neurosci, 7 () : 246

109   Chatelain F.C., Bichet D., Feliciangeli S., Larroque M.M., Braud V.M., Douguet D. and Lesage F. (2013). Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. J Biol Chem, 288 (49) : 35081-92

108   Wang S., Benamer N., Zanella S., Kumar N.N., Shi Y., Bevengut M., Penton D., Guyenet P.G., Lesage F., Gestreau C., Barhanin J. and Bayliss D.A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons. J Neurosci, 33 (41) : 16033-16044

107   Stebe S., Schellig K., Lesage F., Breer H. and Fleischer J. (2014). The Thermosensitive Potassium Channel TREK-1 Contributes to Coolness-Evoked Responses of Grueneberg Ganglion Neurons. Cell Mol Neurobiol, 34 (1) : 113-22

106   Chatelain F.C., Mazzuca M., Larroque M.M., Rogemond V., Honnorat J. and Lesage F. (2013). An ion channel chip for diagnosis and prognosis of autoimmune neurological disorders. Recent Pat CNS Drug Discov, 8 (3) : 171-9

105   Bandulik S., Tauber P., Penton D., Schweda F., Tegtmeier I., Sterner C., Lalli E., Lesage F., Hartmann M., Barhanin J. and Warth R. (2013). Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology, 154 (8) : 2712-22

104   Sandoz G. and Levitz J. (2013). Optogenetic techniques for the study of native potassium channels. Front Mol Neurosci, 6 () : 6

103   Hao J., Padilla F., Dandonneau M., Lavebratt C., Lesage F., Noel J. and Delmas P. (2013). Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron, 77 (5) : 899-914

102   Sandoz G. and Isacoff E.Y. (2012). [Optical remote control of native ion channels]. Med Sci (Paris), 28 (11) : 934-7

101   Mirkovic K., Palmersheim J., Lesage F. and Wickman K. (2012). Behavioral characterization of mice lacking Trek channels. Front Behav Neurosci, 6 () : 60

100   Tadmouri A., Kiyonaka S., Barbado M., Rousset M., Fablet K., Sawamura S., Bahembera E., Pernet-Gallay K., Arnoult C., Miki T., Sadoul K., Gory-Faure S., Lambrecht C., Lesage F., Akiyama S., Khochbin S., Baulande S., Janssens V., Andrieux A., Dolmetsch R., Ronjat M., Mori Y. and De Waard M. (2012). Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J, 31 (18) : 3730-44

99   Penton D., Bandulik S., Schweda F., Haubs S., Tauber P., Reichold M., Cong L.D., El Wakil A., Budde T., Lesage F., Lalli E., Zennaro M.C., Warth R. and Barhanin J. (2012). Task3 potassium channel gene invalidation causes low Renin and salt-sensitive arterial hypertension. Endocrinology, 153 (10) : 4740-8

98   Peyronnet R., Sharif-Naeini R., Folgering J.H., Arhatte M., Jodar M., El Boustany C., Gallian C., Tauc M., Duranton C., Rubera I., Lesage F., Pei Y., Peters D.J., Somlo S., Sachs F., Patel A., Honore E. and Duprat F. (2012). Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K(2P) Channels. Cell Rep, 1 (3) : 241-50

97   Sandoz G., Levitz J., Kramer R.H. and Isacoff E.Y. (2012). Optical Control of Endogenous Proteins with a Photoswitchable Conditional Subunit Reveals a Role for TREK1 in GABA(B) Signaling. Neuron, 74 (6) : 1005-14

96   Moha Ou Maati H., Borsotto M., Chatelain F., Widmann C., Lazdunski M. and Heurteaux C. (2012). Activation of ATP-sensitive potassium channels as an element of the neuroprotective effects of the Traditional Chinese Medicine MLC901 against oxygen glucose deprivation. Neuropharmacology, 63 (4) : 692-700

95   Chatelain FC., Bichet D., Douguet D., Feliciangeli S., Bendahhou S., Reichold M., Warth R., Barhanin J. and Lesage F. (2012). TWIK1, a unique background channel with variable ion selectivity. Proc Natl Acad Sci U S A, 109 (14) : 5499-5504

94   Lesage F. and Barhanin J. (2011). Molecular physiology of pH-sensitive background K2P channels. Physiology, 26 (6) : 424-437

93   Nol J., Sandoz G. and Lesage F. (2011). Molecular regulations governing TREK and TRAAK functions. Channels, 5 (5) : 402-409

92   Janovjak H., Sandoz G. and Isacoff E.Y. (2011). A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence. Nat Commun, 2 () : 232

91   Sandoz G., Bell S.C. and Isacoff E.Y. (2011). Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci U S A, 108 (6) : 2605-10

90   Gestreau C., Heitzmann D., Thomas J., Dubreuil V., Bandulik S., Reichold M., Bendahhou S., Pierson P., Sterner C., Peyronnet-Roux J., Benfriha C., Tegtmeier I., Ehnes H., Georgieff M., Lesage F., Brunet JF., Goridis C., Warth R. and Barhanin J. (2010). Task2 potassium channels set central respiratory CO2 and O2 sensitivity Proc Natl Acad Sci U S A, 107 (5) : 2325-2330

89   Feliciangeli S., Tardy MP., Sandoz G.,Chatelain F., Warth R., Barhanin J., Bendahhou S. and Lesage F. (2010). Potassium channel silencing by constitutive endocytosis and intracellular sequestration J Biol Chem, 285 (7) : 4798-4805

88   Chatelain F.C., Gazzarrini S., Fujiwara Y., Arrigoni C., Domigan C., Ferrara G., Pantoja C., Thiel G., Moroni A. and Minor DL J.r. (2009). Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block. PLoS One, 4 (10) : e7496

87   Sandoz G., Douguet D., Chatelain F., Lazdunski M. and Lesage F. (2009). Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue Proc Natl Acad Sci U S A, 106 (34) : 146268-14633

86   Burdakov D. and Lesage F. (2010). Glucose-induced inhibition: how many ionic mechanisms? Acta Physiol (Oxf)., 198 (3) : 295-301

85   Guyon A., Tardy MP., Rovre C., Nahon JL., Barhanin J. and Lesage F. (2009). Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels J Neurosci. , 29 (8) : 2528-2533

84   Sandoz G. and lesage F. (2008). Protein complex analysis of native brain potassium channels by proteomics Methods Mol Biol, 491 () : 113-123

83   Sandoz G., Tardy M., Thummler S., Feliciangeli S., Lazdunski M. and lesage F. (2008). Mtap2 is a constituent of the protein network that regulates TREK channel expression and trafficking J Neurosci , 28 (34) : 8545-8545

82   Heitzmann D., Derand R., Jungbauer S., Bandulik S., Sterner C., Schweda F., El Wakil A., Lalli E., Guy N., Mengual R., Reichold M., Tegtmeier I., Bendahhou S., Gomez-Sanchez C.E., Aller M.I., Wisden W., Weber A., Lesage F., Warth R. and Barhanin J. (2008). Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis EMBO J, 27 (1) : 179-87

81   Feliciangeli S., Bendahhou S., Sandoz G., Gounon P., Reichold M., Warth R., Lazdunski M., Barhanin J. and Lesage F. (2007). Does Sumoylation Control K2P1/TWIK1 Background K+ Channels? Cell, 130 (3) : 563-9

80   Mazzuca M. and Lesage F. (2007). Potassium channels, genetic and acquired diseases. Rev Med Interne, 28 (8) : 576-579

79   Sandoz G., Thummler S., Duprat F., Feliciangeli S., Vinh J., Escoubas P., Guy N., Lazdunski M. and Lesage F. (2006). AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K+ channels into open leak channels EMBO J, 25 (24) : 5864-72

78   Mazzuca M., Lesage F and Lazdunski M. (2006). Ion channels and epilepsy. Epileptic Disord, 8 () : S1-16

77   Zanzouri M., Lauritzen I., Duprat F., Mazzuca M., Lesage F., Lazdunski M. and Patel A. (2006). Membrane potential-regulated transcription of the resting K+ conductance J Biol Chem, 281 (39) : 28910-8

76   Goldstein S.A., Bayliss D.A., Kim D., Lesage F., Plant L.D. and Rajan S. (2005). International Union of Pharmacology. LV. Nomenclature and molecular Pharmacol Rev, 57 (4) : 527-40

75   Ebensperger G., Ebensperger R., Herrera E.A., Riquelme R.A., Sanhueza E.M., Lesage F., Marengo J.J., Tejo R.I., Llanos A.J. and Reyes R.V. (2005). Fetal brain hypometabolism during prolonged hypoxaemia in the llama. J Physiol, 567 (Pt 3) : 963-75

74   Mazzuca M., Lesage F. and Lazdunski M. (2004). Canaux ioniques et pilepsie. Epileptic Disord, 6 (S1) : S1-16

73   Vamecq J., Vallee L., Lesage F., Gressens P. and Stables J.P. (2005). Antiepileptic popular ketogenic diet: emerging twists in an ancient story. Prog Neurobiol, 75 (1) : 1-28

72   Decressac S., Franco M., Bendahhou S., Warth R., Knauer S., Barhanin J., Lazdunski M. and Lesage F. (2004). ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6 EMBO Rep, 5 (12) : 1171-5

71   Nicolas M.T., Lesage F., Reyes R., Barhanin J. and Dememes D. (2004). Localization of TREK-1, a two-pore-domain K+ channel in the peripheral Brain Res, 1017 (1-2) : 46-52

70   Girard C. and Lesage F. (2004). Neuronal background two-P-domain potassium channels: molecular and Med Sci (Paris), 20 (5) : 544-9

69   Warth R., Barriere H., Meneton P., Bloch M., Thomas J., Tauc M., Heitzmann D., Romeo E., Verrey F., Mengual R., Guy N., Bendahhou S., Lesage F., Poujeol P. and Barhanin J. (2004). Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals Proc Natl Acad Sci U S A, 101 (21) : 8215-20

68   Lesage F., Hibino H. and Hudspeth A.J. (2004). Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels Proc Natl Acad Sci U S A, 101 (2) : 671-5

67   Gutman G.A., Chandy K.G., Adelman J.P., Aiyar J., Bayliss D.A., Clapham D.E., Covarriubias M., Desir G.V., Furuichi K., Ganetzky B., Garcia M.L., Grissmer S., Jan L.Y., Karschin A., Kim D., Kuperschmidt S., Kurachi Y., Lazdunski M., Lesage F., Lester H.A., McKinnon D., Nichols C.G., O'Kelly I., Robbins J., Robertson G.A., Rudy B., Sanguinetti M., Seino S., Stuehmer W., Tamkun M.M., Vandenberg C.A., Wei A., Wulff H. and Wymore R.S. (2003). International Union of Pharmacology. XLI. Compendium of voltage-gated ion Pharmacol Rev, 55 (4) : 583-6

66   Chemin J., Girard C., Duprat F., Lesage F., Romey G. and Lazdunski M. (2003). Mechanisms underlying excitatory effects of group I metabotropic glutamate EMBO J, 22 (20) : 5403-11

65   Barriere H., Belfodil R., Rubera I., Tauc M., Lesage F., Poujeol C., Guy N., Barhanin J. and Poujeol P. (2003). Role of TASK2 potassium channels regarding volume regulation in primary J Gen Physiol, 122 (2) : 177-90

64   Magloire H., Lesage F., Couble M.L., Lazdunski M. and Bleicher F. (2003). Expression and localization of TREK-1 K+ channels in human odontoblasts. J Dent Res, 82 (7) : 542-5

63   Lesage F. (2003). Pharmacology of neuronal background potassium channels. Neuropharmacology, 44 (1) : 1-7

62   Hibino H., Pironkova R., Onwumere O., Rousset M., Charnet P., Hudspeth A.J. and Lesage F. (2003). Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit Proc Natl Acad Sci U S A, 100 (1) : 307-12

61   Hibino H., Pironkova R., Onwumere O., Vologodskaia M., Hudspeth A.J. and Lesage F. (2002). RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels Neuron, 34 (3) : 411-23

60   Terrenoire C., Lauritzen I., Lesage F., Romey G. and Lazdunski M. (2001). A TREK-1-like potassium channel in atrial cells inhibited by Circ Res, 89 (4) : 336-42

59   Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G., Lazdunski M. and Lesage F. (2001). Genomic and functional characteristics of novel human pancreatic 2P domain Biochem Biophys Res Commun, 282 (1) : 249-56

58   Lesage F., Barhanin J. and Meneton P. (2000). Potassium transport: molecular and pathophysiological aspects. Med Sci (Paris), 16 (5) : 663-72

57   Lesage F. and Lazdunski M. (2000). Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol, 279 (5) : F793-801

56   Lesage F., Terrenoire C., Romey G. and Lazdunski M. (2000). Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple J Biol Chem, 275 (37) : 28398-405

55   Czirjak G., Fischer T., Spat A., Lesage F. and Enyedi P. (2000). TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa Mol Endocrinol, 14 (6) : 863-74

54   Maingret F., Lauritzen I., Patel A.J., Heurteaux C., Reyes R., Lesage F., Lazdunski M. and Honore E. (2000). TREK-1 is a heat-activated background K(+) channel. EMBO J, 19 (11) : 2483-91

53   Bearzatto B., Lesage F., Reyes R., Lazdunski M. and Laduron P.M. (2000). Axonal transport of TREK and TRAAK potassium channels in rat sciatic Neuroreport, 11 (5) : 927-30

52   Duprat F., Lesage F., Patel A.J., Fink M., Romey G. and Lazdunski M. (2000). The neuroprotective agent riluzole activates the two P domain K(+) Mol Pharmacol, 57 (5) : 906-12

51   Lesage F., Maingret F. and Lazdunski M. (2000). Cloning and expression of human TRAAK, a polyunsaturated fatty FEBS Lett, 471 (2-3) : 137-40

50   Maingret F., Patel A.J., Lesage F., Lazdunski M. and Honore E. (2000). Lysophospholipids open the two-pore domain mechano-gated K(+) channels J Biol Chem, 275 (14) : 10128-33

49   Reyes R., Lauritzen I., Lesage F., Ettaiche M., Fosset M. and Lazdunski M. (2000). Immunolocalization of the arachidonic acid and mechanosensitive baseline Neuroscience, 95 (3) : 893-901

48   Meneton P., Lesage F. and Barhanin J. (1999). Potassium ATPases, channels, and transporters: an overview. Semin Nephrol, 19 (5) : 438-57

47   Maingret F., Patel A.J., Lesage F., Lazdunski M. and Honore E. (1999). Mechano- or acid stimulation, two interactive modes of activation of the J Biol Chem, 274 (38) : 26691-6

46   Lopez-Coronado J.M., Belles J.M., Lesage F., Serrano R. and Rodriguez P.L. (1999). A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, J Biol Chem, 274 (23) : 16034-9

45   Patel A.J., Honore E., Lesage F., Fink M., Romey G. and Lazdunski M. (1999). Inhalational anesthetics activate two-pore-domain background K+ channels. Nat Neurosci, 2 (5) : 422-6

44   Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G. and Lazdunski M. (1999). Cloning of a new mouse two-P domain channel subunit and a human homologue J Biol Chem, 274 (17) : 11751-60

43   Maingret F., Fosset M., Lesage F., Lazdunski M. and Honore E. (1999). TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem, 274 (3) : 1381-7

42   Cluzeaud F., Reyes R., Escoubet B., Fay M., Lazdunski M., Bonvalet J.P., Lesage F. and Farman N. (1998). Expression of TWIK-1, a novel weakly inward rectifying potassium channel Am J Physiol, 275 (6 Pt 1) : C1602-9

41   Reyes R., Duprat F., Lesage F., Fink M., Salinas M., Farman N. and Lazdunski M. (1998). Cloning and expression of a novel pH-sensitive two pore domain K+ channel J Biol Chem, 273 (47) : 30863-9

40   Lesage F. and Lazdunski M. (1998). Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) Genomics, 51 (3) : 478-9

39   Patel A.J., Honore E., Maingret F., Lesage F., Fink M., Duprat F. and Lazdunski M. (1998). A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J, 17 (15) : 4283-90

38   Fink M., Lesage F., Duprat F., Heurteaux C., Reyes R., Fosset M. and Lazdunski M. (1998). A neuronal two P domain K+ channel stimulated by arachidonic acid and EMBO J, 17 (12) : 3297-308

37   Arrighi I., Lesage F., Scimeca J.C., Carle G.F. and Barhanin J. (1998). Structure, chromosome localization, and tissue distribution of the mouse FEBS Lett, 425 (2) : 310-6

36   Duprat F., Lesage F., Fink M., Reyes R., Heurteaux C. and Lazdunski M. (1997). TASK, a human background K+ channel to sense external pH variations near EMBO J, 16 (17) : 5464-71

35   Murer G., Adelbrecht C., Lauritzen I., Lesage F., Lazdunski M., Agid Y. and Raisman-Vozari R. (1997). An immunocytochemical study on the distribution of two G-protein-gated Neuroscience, 80 (2) : 345-57

34   Adelbrecht C., Murer M.G., Lauritzen I., Lesage F., Ladzunski M., Agid Y. and Raisman-Vozari R. (1997). An immunocytochemical study of a G-protein-gated inward rectifier K+ Neuroreport, 8 (4) : 969-74

33   Lauritzen I., De Weille J., Adelbrecht C., Lesage F., Murer G., Raisman-Vozari R. and Lazdunski M. (1997). Comparative expression of the inward rectifier K+ channel GIRK2 in the Brain Res, 753 (1) : 8-17

32   Lesage F., Lauritzen I., Duprat F., Reyes R., Fink M., Heurteaux C. and Lazdunski M. (1997). The structure, function and distribution of the mouse TWIK-1 K+ channel. FEBS Lett, 402 (1) : 28-32

31   Fink M., Duprat F., Lesage F., Reyes R., Romey G., Heurteaux C. and Lazdunski M. (1996). Cloning, functional expression and brain localization of a novel EMBO J, 15 (24) : 6854-62

30   Vetter D.E., Mann J.R., Wangemann P., Liu J., McLaughlin K.J., Lesage F., Marcus D.C., Lazdunski M., Heinemann S.F. and Barhanin J. (1996). Inner ear defects induced by null mutation of the isk gene. Neuron, 17 (6) : 1251-64

29   Lesage F., Reyes R., Fink M., Duprat F., Guillemare E. and Lazdunski M. (1996). Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J, 15 (23) : 6400-7

28   Barhanin J., Lesage F., Guillemare E., Fink M., Lazdunski M. and Romey G. (1996). K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac Nature, 384 (6604) : 78-80

27   Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J. and Lazdunski M. (1996). A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) J Biol Chem, 271 (42) : 26341-8

26   Hugnot J.P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.G. and Lazdunski M. (1996). Kv8.1, a new neuronal potassium channel subunit with specific inhibitory EMBO J, 15 (13) : 3322-31

25   Lesage F., Mattei M., Fink M., Barhanin J. and Lazdunski M. (1996). Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to Genomics, 34 (1) : 153-5

24   Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G. and Barhanin J. (1996). A pH-sensitive yeast outward rectifier K+ channel with two pore domains J Biol Chem, 271 (8) : 4183-7

23   Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G. and Barhanin J. (1996). TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a EMBO J, 15 (5) : 1004-11

22   Lesage F., Fink M., Barhanin J., Lazdunski M. and Mattei M.G. (1995). Assignment of human G-protein-coupled inward rectifier K+ channel homolog Genomics, 29 (3) : 808-9

21   Fink M., Duprat F., Heurteaux C., Lesage F., Romey G., Barhanin J. and Lazdunski M. (1996). Dominant negative chimeras provide evidence for homo and heteromultimeric FEBS Lett, 378 (1) : 64-8

20   Duprat F., Guillemare E., Romey G., Fink M., Lesage F., Lazdunski M. and Honore E. (1995). Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci U S A, 92 (25) : 11796-800

19   Chevillard C., Attali B., Lesage F., Fontes M., Barhanin J., Lazdunski M. and Mattei M.G. (1993). Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in Genomics, 15 (1) : 243-5

18   Attali B., Guillemare E., Lesage F., Honore E., Romey G., Lazdunski M. and Barhanin J. (1993). The protein IsK is a dual activator of K+ and Cl- channels. Nature, 365 (6449) : 850-2

17   Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.P., Mattei M.G., Lazdunski M. and Barhanin J. (1993). Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier J Biol Chem, 268 (32) : 24283-9

16   Honore E., Barhanin J., Attali B., Lesage F. and Lazdunski M. (1994). External blockade of the major cardiac delayed-rectifier K+ channel Proc Natl Acad Sci U S A, 91 (5) : 1937-41

15   Lesage F., Attali B., Lakey J., Honore E., Romey G., Faurobert E., Lazdunski M. and Barhanin J. (1993). Are Xenopus oocytes unique in displaying functional IsK channel Receptors Channels, 1 (2) : 143-52

14   Honore E., Lesage F. and Romey G. (1994). Molecular biology of voltage-gated K+ channels in heart. Fundam Clin Pharmacol, 8 (2) : 108-16

13   Lesage F., Hugnot J.P., Amri E.Z., Grimaldi P., Barhanin J. and Lazdunski M. (1994). Expression cloning in K+ transport defective yeast and distribution of Nucleic Acids Res, 22 (18) : 3685-8

12   Lesage F., Duprat F., Fink M., Guillemare E., Coppola T., Lazdunski M. and Hugnot J.P. (1994). Cloning provides evidence for a family of inward rectifier and G-protein FEBS Lett, 353 (1) : 37-42

11   Duprat F., Lesage F., Guillemare E., Fink M., Hugnot J.P., Bigay J., Lazdunski M., Romey G. and Barhanin J. (1995). Heterologous multimeric assembly is essential for K+ channel activity of Biochem Biophys Res Commun, 212 (2) : 657-63

10   Honore E., Guillemare E., Lesage F., Barhanin J. and Lazdunski M. (1994). Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to FEBS Lett, 348 (3) : 259-62

9   Lesage F., Guillemare E., Fink M., Duprat F., Heurteaux C., Fosset M., Romey G., Barhanin J. and Lazdunski M. (1995). Molecular properties of neuronal G-protein-activated inwardly rectifying J Biol Chem, 270 (48) : 28660-7

8   Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F., Lazdunski M. and Barhanin J. (1991). Cloning, expression, pharmacology and regulation of a delayed rectifier K+ EMBO J, 10 (10) : 2805-11

7   Attali B., Honore E., Lesage F., Lazdunski M. and Barhanin J. (1992). Regulation of a major cloned voltage-gated K+ channel from human T FEBS Lett, 303 (2-3) : 229-32

6   Lesage F., Attali B., Lazdunski M. and Barhanin J. (1992). ISK, a slowly activating voltage-sensitive K+ channel. Characterization of FEBS Lett, 301 (2) : 168-72

5   Lesage F., Attali B., Lazdunski M. and Barhanin J. (1992). Developmental expression of voltage-sensitive K+ channels in mouse FEBS Lett, 310 (2) : 162-6

4   Honore E., Attali B., Romey G., Lesage F., Barhanin J. and Lazdunski M. (1992). Different types of K+ channel current are generated by different levels of EMBO J, 11 (7) : 2465-71

3   Honore E., Attali B., Lesage F., Barhanin J. and Lazdunski M. (1992). Receptor-mediated regulation of IsK, a very slowly activating, Biochem Biophys Res Commun, 184 (3) : 1135-41

2   Attali B., Romey G., Honore E., Schmid-Alliana A., Mattei M.G., Lesage F., Ricard P., Barhanin J. and Lazdunski M. (1992). Cloning, functional expression, and regulation of two K+ channels in human J Biol Chem, 267 (12) : 8650-7

1   Guillemare E., Honore E., Pradier L., Lesage F., Schweitz H., Attali B., Barhanin J. and Lazdunski M. (1992). Effects of the level of mRNA expression on biophysical properties, Biochemistry, 31 (49) : 12463-8