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NEWS
Gérard Lambeau/ Prix Jean Valade
Fondation de France

Gérard LAMBEAU, team leader at the IPMC, is a senior laureate of the Jean Valade Foundation for his project "Revolution in the medical follow-up of glomerulonephritis". 
Publication IPMC/ Nature Communications
Understanding the impact of the FMR1 gene in fragile X syndrome

Stéphane Martin's team, Inserm Research Director at the Institute of Molecular and Cellular Pharmacology (IPMC - Université Côte d'Azur / CNRS), has published a study in the journal Nature Communications showing that induction of a mutation in the FMR1 gene in mice, which is known to be involved in Fragile X syndrome in humans, causes deterioration in neuronal communication and socio-cognitive deficits. 
IPMC/ Veolia, CNRS and Côte d'Azur University are tracking SARS-CoV-2 variants in waste water
 
The research team of Pascal Barbry, CNRS research director, and VEOLIA are collaborating on the sequencing of SARSCoV2 variants in wastewater.
 

IPMC/ Promotion of the National Order of Merit

Two civilian promotions of the Legion of Honour and the National Order of Merit are published in the Official Gazette on 1 January 2021. Among the 3884 newly decorated, 63% are for their commitment in the fight against the Covid-19, as wished by the President of the Republic, Grand Master of the National Orders.
We congratulate Catherine Le Calvez, our Health and Safety Coordinator, for her title of Chevalier de l'Ordre National du Mérite.
Clarivate / 4 Côte d'Azur researchers in the list of "Highly Cited Researchers"

This annual list identifies the 6,100 researchers who have demonstrated a significant influence in their field(s) of interest through the publication of several highly cited articles over the past decade.
Congratulations to the Côte d'Azur researchers included in this 2020 ranking, and in particular to :
- Jean Mazella, CNRS Research Director at IPMC (CNRS-University Côte d'Azur)
- Jean-Louis Nahon, CNRS Research Director at the IPMC (CNRS-University Côte d'Azur) and Director of the IPMC.
IPMC/ Genome Research Publication
Pharmacological functional sorting

Scientists from the IPMC (CNRS-University Côte d'Azur), including Barbara Bardoni, Inserm research director at the IPMC, have just published an article in the journal Genome Research. The team has developed a new method of dynamic pharmacological functional sorting that makes it possible to stimulate, record and select neurons according to their response to identical stimulation, in real time.
IPMC/ Acta Neuropathologica Publication
Failure to eliminate defective mitochondria at the heart of Alzheimer's disease
 
In a work published in Acta Neuropathologica, Dr. Chami Mounia, CR Inserm at the Institute of Molecular and Cellular Pharmacology (IPMC - UCA/CNRS) and his collaborators demonstrate the role of the accumulation of different toxic fragments of the amyloid peptide β (Aβ) in mitochondrial dysfunction occurring in the context of Alzheimer's disease.

Innovations that will change the world,
by the C.U.R.I.E. network

 
The Spadine concept for fighting depression arises from the observation that a naturally occurring peptide, the propeptide resulting from the maturation of the sortilin protein, is able to block the activity of the TREK-1 potassium channel, itself involved in the pathology of depression.

A CHAMPION AT IPMC...


Yohan Viani completed the Grande Traversée du Mercantour this weekend (220 km and 13,000 m of vertical drop) in 46h 11 '...
Publication IPMC/Nat. Commun

Read the RNA all the way through, cell by cell
 
Scientists describe a new method to more finely analyze the structure of RNAs to detect splicing or editing variations with resolution down to the single cell. These approaches, which combine microfluidic tools with nucleic acid sequencing over long lengths, will improve the construction of the single cell atlases that are currently being developed. These results are published in the journal Nature Communications.
Publication IPMC/Cancers

Neutrophils, immune cells at the service of skin carcinomas!
 
Cutaneous squamous cell carcinoma (SCC), the 2nd most deadly skin cancer, is associated with immunosuppression and neutrophil infiltration. Comparison of the gene expression profile of neutrophils isolated from the skin or of CEC shows that the tumour environment has perverted their function so that they participate in the inhibition of anti-tumour immune responses mediated by cytotoxic T lymphocytes. This study is published in the journal Cancers (Basel).

Publication IPMC/LP2M
J Cereb Blood Flow Metab  (JCBFM)


A new pharmacological avenue in the treatment of stroke
 
A work published in the journal J Cereb Blood Flow Metab (JCBFM) characterizes a new therapeutic target in stroke. These data show that inhibition of an enzyme linked to the polyamine synthesis pathway reduces neuronal damage and improves functional (motor and cognitive) recovery in different models of ischemic stroke. As this metabolic pathway has been the subject of therapeutic modulator development in other diseases, this study could have a significant impact on the direction of research into new drugs for stroke.
 
Publication IPMC/Sciences Advances
 
XAF1 as a modifier of p53 function and cancer susceptibility.
 
Somatic mutations in the TP53 gene are one of the most common alterations in human cancers, and germline mutations in this gene are the cause of Li-Fraumeni syndrome, which predisposes to a wide range of cancers. This study, published in the journal Science Advances, shows that a mutation in the XAF1 gene modulates the probability of cancer occurrence (penetrance) in carriers of the TP53 p.R337H mutation ("Brazilian mutation"), which is widespread in the population of the southern states of Brazil.
EVENTS

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PUBLICATIONS
 Delfosse V. et al. (2020). Structural and Functional Specialization of OSBP-Related Proteins Contact

 Di Marco B. et al. (2021). Fragile X mental retardation protein (FMRP) and metabotropic glutamate receptor subtype 5 (mGlu5) control stress granule formation in astrocytes. Neurobiol Dis

 Mantegazza M. et al. (2021). Sodium Channelopathies of Skeletal Muscle and Brain. Physiol Rev

 Montnach J. et al. (2021). Fluorescent- and tagged-protoxin II peptides: potent markers of the Na(v) 1.7 channel pain target. Br J Pharmacol

 Paris A.L. et al. (2021). Sublingual vaccination and delivery systems. J Control Release

 Fernandez A. et al. (2021). A novel microduplication in INPP5A segregates with schizophrenia spectrum disorder in the family of a patient with both childhood onset schizophrenia and autism spectrum disorder. Am J Med Genet A

 Prieto M. et al. (2021). Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice. Nat Commun

 Macia E. et al. (2021). Chlortetracycline, a Novel Arf Inhibitor That Decreases the Arf6-Dependent Invasive Properties of Breast Cancer Cells. Molecules

VIDEO
Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
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