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NEWS
Innovations that will change the world,
by the C.U.R.I.E. network
The Spadine concept for fighting depression arises from the observation that a naturally occurring peptide, the propeptide resulting from the maturation of the sortilin protein, is able to block the activity of the TREK-1 potassium channel, itself involved
in the pathology of depression.

A CHAMPION AT IPMC...


Yohan Viani completed the Grande Traversée du Mercantour this weekend (220 km and 13,000 m of vertical drop) in 46h 11 '...
Publication IPMC/Nat. Commun

Neutrophils, immune cells at the service of skin carcinomas!
 
Scientists describe a new method to more finely analyze the structure of RNAs to detect splicing or editing variations with resolution down to the single cell. These approaches, which combine microfluidic tools with nucleic acid sequencing over long lengths, will improve the construction of the single cell atlases that are currently being developed. These results are published in the journal Nature Communications.
Publication IPMC/Cancers

Neutrophils, immune cells at the service of skin carcinomas!
 
Cutaneous squamous cell carcinoma (SCC), the 2nd most deadly skin cancer, is associated with immunosuppression and neutrophil infiltration. Comparison of the gene expression profile of neutrophils isolated from the skin or of CEC shows that the tumour environment has perverted their function so that they participate in the inhibition of anti-tumour immune responses mediated by cytotoxic T lymphocytes. This study is published in the journal Cancers (Basel).

Publication IPMC/LP2M
J Cereb Blood Flow Metab  (JCBFM)


A new pharmacological avenue in the treatment of stroke
 
A work published in the journal J Cereb Blood Flow Metab (JCBFM) characterizes a new therapeutic target in stroke. These data show that inhibition of an enzyme linked to the polyamine synthesis pathway reduces neuronal damage and improves functional (motor and cognitive) recovery in different models of ischemic stroke. As this metabolic pathway has been the subject of therapeutic modulator development in other diseases, this study could have a significant impact on the direction of research into new drugs for stroke.
 
Publication IPMC/Sciences Advances
 
XAF1 as a modifier of p53 function and cancer susceptibility.
 
Somatic mutations in the TP53 gene are one of the most common alterations in human cancers, and germline mutations in this gene are the cause of Li-Fraumeni syndrome, which predisposes to a wide range of cancers. This study, published in the journal Science Advances, shows that a mutation in the XAF1 gene modulates the probability of cancer occurrence (penetrance) in carriers of the TP53 p.R337H mutation ("Brazilian mutation"), which is widespread in the population of the southern states of Brazil.
Publication IPMC/ICN
 
The collaboration between Isabelle Mus-Veteau, a biologist from the IPMC (CNRS, Sophia Antipolis) and Stéphane Azoulay, a chemist from the ICN (Côte d'Azur University), has shown that a small molecule produced by a Mediterranean sponge and then synthesized by the chemists reduces the resistance to vémurafenib of BRAFV600E mutated melanomas expressing the patched receptor and increases the efficacy of the treatment in mice.
 
New Chairs for 3iA Côte d'Azur

The list of new 3iA Côte d'Azur Chairs has been announced.
For theme 3 "AI for Computational Biology and Bio-Inspired AI", Pascal Barbry, CNRS Research Director at IPMC (CNRS-Université Côte d'Azur) has been selected: "Human Lung Atlas".
 
COVID19: PCR Tests: "We'll be able to reach 50,000 per week."
 
André Le Bivic, Director of the Institute of Biological Sciences, explains the call for public research laboratories and their mobilization to carry out tests for COVID-19.
EVENTS

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PUBLICATIONS
 Delfosse V. et al. (2020). Structural and Functional Specialization of OSBP-Related Proteins Contact

 Di Mattia T. et al. (2020). FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. EMBO J

 Vaillant-Beuchot L. et al. (2020). Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains. Acta Neuropathol

 Caballero I. et al. (2020). Evidence of early increased sialylation of airway mucins and defective mucociliary clearance in CFTR-deficient piglets. J Cyst Fibros

 Castagnola S. et al. (2020). Agonist-induced Functional Analysis and Cell Sorting coupled with single-cell transcriptomics characterizes cell subtypes in normal and pathological brain. Genome Res

 Busserolles J. et al. (2020). TREK-1 channel activation as a new analgesic strategy devoid of opioid adverse effects. Br J Pharmacol

 Culotta L. et al. (2020). SULT4A1 modulates synaptic development and function by promoting the formation of PSD-95/NMDAR complex. J Neurosci

 Lipp N.F. et al. (2020). Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism. Front Cell Dev Biol

VIDEO
Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
CONFERENCES & THESIS
Friday, November 13th 2020 at 2: PM : :
Thèse soutenue par Marine GAUTIER-ISOLA (dir. Roger Rezzonico) :
Caractérisation fonctionnelle de longs ARNs non codants induits par l’hypoxie et impliqués dans l’agressivité des cancers pulmonaires non à petites cellules

Monday, November 16th 2020 at 2: PM : :
Thèse soutenue par Nicolas-Frédéric LIPP (dir. Guillaume Drin) :
Fonctionnement des échangeurs phosphatidylsérine / phosphatidylinositol 4-phosphate à l'interface réticulum endoplasmique / membrane plasmique

Friday, December 11th 2020 at 11: AM : :
Jean-Louis Nahon invite le Pr. Paolo Giacobini :
AMH signaling in GnRH neurons: wiring the brain to reproductive function and dysfunction

Thursday, December 17th 2020 at 2:30 PM : :
Thèse soutenue par Meng-Chen TSAI (dir. Hélène Barelli & Emmanuel Lemichez) :
Les phospholipides polyinsaturés dans les larges déformations membranaires induites par les toxines bactériennes

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INSTITUT DE PHARMACOLOGIE MOLECULAIRE ET CELLULAIRE

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