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Publication IPMC/LP2M
J Cereb Blood Flow Metab  (JCBFM)

A new pharmacological avenue in the treatment of stroke
A work published in the journal J Cereb Blood Flow Metab (JCBFM) characterizes a new therapeutic target in stroke. These data show that inhibition of an enzyme linked to the polyamine synthesis pathway reduces neuronal damage and improves functional (motor and cognitive) recovery in different models of ischemic stroke. As this metabolic pathway has been the subject of therapeutic modulator development in other diseases, this study could have a significant impact on the direction of research into new drugs for stroke.
Sciences Advances

XAF1 as a modifier of p53 function and cancer susceptibility.
Somatic mutations in the TP53 gene are one of the most common alterations in human cancers, and germline mutations in this gene are the cause of Li-Fraumeni syndrome, which predisposes to a wide range of cancers. This study, published in the journal Science Advances, shows that a mutation in the XAF1 gene modulates the probability of cancer occurrence (penetrance) in carriers of the TP53 p.R337H mutation ("Brazilian mutation"), which is widespread in the population of the southern states of Brazil.
Publication IPMC/ICN
The collaboration between Isabelle Mus-Veteau, a biologist from the IPMC (CNRS, Sophia Antipolis) and Stéphane Azoulay, a chemist from the ICN (Côte d'Azur University), has shown that a small molecule produced by a Mediterranean sponge and then synthesized by the chemists reduces the resistance to vémurafenib of BRAFV600E mutated melanomas expressing the patched receptor and increases the efficacy of the treatment in mice.
New Chairs for 3iA Côte d'Azur

The list of new 3iA Côte d'Azur Chairs has been announced.
For theme 3 "AI for Computational Biology and Bio-Inspired AI", Pascal Barbry, CNRS Research Director at IPMC (CNRS-Université Côte d'Azur) has been selected: "Human Lung Atlas".
COVID19: PCR Tests: "We'll be able to reach 50,000 per week."
André Le Bivic, Director of the Institute of Biological Sciences, explains the call for public research laboratories and their mobilization to carry out tests for COVID-19.
CNRS INSB 2019 Scientific Report / Côte d'Azur scientists in the spotlight!
The INSB 2019 report has been published on the website of the Institute of Biology of the CNRS. This document is an overview of scientific activity in the field of biological sciences in 2019.
The publications of certain Côte d'Azur researchers are highlighted, including researchers from the IPMC : Marc Borsotto (DR CNRS, page25), Takeshi Harayama (chercheur en CDD, page 31), Jacques Barik (MCF UCA, page 42) & Thomas Bertero (CR CNRS, page 43).
IPMC/ Sophia Mag/ Behavioural disorders: it’s not all in the mind

In an immunology laboratory in Sophia Antipolis, «psychiatry» is spelt “psych-AItry». Why are immunologists joining up with psychiatrists, and what is more, accompanied by Artificial Intelligence? Susana Barbosa works in Nicolas Glaichenhaus’ team at the Institut de Pharmacologie Moléculaire et Cellulaire. The team is entitled “Immune system, brain and peripheral nerves” and aims, among other things, at identifying immune biomarkers in blood with the intent to better diagnose mental illness.
Publication Cell Reports 2020
You've just finished a good meal and you feel full? Researchers from the CNRS, Inrae, the University of Burgundy, the University of Paris, Inserm and the University of Luxembourg have just understood the mechanisms in your brain that led to this state. It is a cascade of reactions triggered by an increase in blood glucose levels. This study, conducted in mice, is published in Cell Reports on March 3, 2020.

IPMC / Publication The Journal of Clinical Investigation
Gérard Lambeau, chercheur CNRS à l'IPMC
(CNRS - Université Côte d'Azur)

IPMC/ Publication of a scientific article in Nature Communications

The team of Florian Lesage, an Inserm researcher at the Institut de Pharmacologie Moléculaire et Cellulaire (CNRS-Université Côte d'Azur), has identified a new therapeutic approach to treat certain neurodevelopmental diseases, in particular Birk Barel syndrome. This work was published in Nature Communications :"Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome"

Florian Lesage, an Inserm researcher at IPMC (CNRS - Université Côte d'Azur)

IPMC / Marie Curie Fellowship Awarded
Aurore Thomazeau, currently a researcher in neuroscience at McGill University in Montreal, has just been awarded an individual "Marie Sklodowska-Curie Actions Global Fellowship" with the METAFRAX project (Unconventional NMDAR signaling theory for Fragile X Syndrome). She will join the team RNA Metabolism and Diseases related to Neurodevelopment of Dr Barbara Bardoni, DR Inserm at IPMC (CNRS-University Côte d'Azur).

Visit of the laboratory by CIV college students

A "Science Professions" morning was organized by Anne Baron, CNRS research fellow at the IPMC in Sophia-Antipolis on Thursday, January 30. The 30 students from a 4th year class at the Centre International de Valbonne were able to attend presentations by scientists and visit the laboratory's imaging, histology, proteomics and lipidomics platforms.

Visit of the laboratory by students from Antibes

A "Science Professions" afternoon was organized this Tuesday, January 21 at the Institute of Molecular and Cellular Pharmacology in Sophia-Antipolis for high school students from the Lycée Horticole Vert d'Azur. A visit to the laboratory's cytometry and imaging platforms was proposed to them to close the visit.
Ceremony to award medals to the three CNRS Talents 2019

The CNRS Talent Medals were awarded on Tuesday 10 December 2019 at the Mediterranean University Centre in Nice. Among the 3 laureates are 2 IPMC researchers, Jacques BARIK and Thomas BERTERO, recipients of the Bronze Medal.



 Spenl C. et al. (2020). Tenascin-C orchestrates an immune suppressive tumor microenvironment in oral squamous cell carcinoma. Cancer Immunol Res

 Khou S. et al. (2020). Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development. Cancers (Basel)

 Signetti L. et al. (2020). Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant Braf(V600E) Melanoma. Cancers (Basel)

 Pothlichet J. Rose T. Bugault F. Jeammet L. Meola A. Haouz A. Saul F. Geny D. Alcami J. Ruiz-Mateos E. Teyton L. Lambeau G. and Theze J. et al. (2020). PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients J Clin Invest

 Jaber S. Goehrig D. Bertolino P. Massemin A. Bihl F. Chabry J. Lambeau G. Vindrieux D. and Bernard D. et al. (2020). Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1 Sci Rep

 Ziegler CG.K. et al. (2020). SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell

 Bcot A. et al. (2020). The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimers Disease Models. Cells

 De Luca D. Shankar-Aguilera S. Autilio C. Raschetti R. Vedovelli L. Fitting C. Payre C. Jeammet L. Perez-Gil J. Cogo P. E. Carnielli V. P. Lambeau G. and Touqui L. et al. (2020). Surfactant-secreted phospholipase A2 interaction and respiratory outcome in preterm neonates Am J Physiol Lung Cell Mol Physiol

Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
Tuesday, September 8th 2020 at 11: AM : :
Bruno MESMIN invite le Kristine SCHAUER :
A venir

Monday, September 14th 2020 at 2: PM : :
HDR soutenue par Thomas BERTERO :
Mcano-mtabolisme : de lchelle tissulaire lchelle molculaire

Friday, December 11th 2020 at 11: AM : :
Jean-Louis Nahon invite le Pr. Paolo Giacobini :
AMH signaling in GnRH neurons: wiring the brain to reproductive function and dysfunction

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