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IPMC will be accredited by Inserm at 2024/01/01

Academy of Sciences

The 2023 Emile Jungfleish Prize of the Academy of Sciences is awarded to Bruno Antonny

STIC Doctoral School Thesis Award 2023
ATSI Specialty Second Prize
Marielle Péré

Thesis title: Modeling single-cell response dynamics to anticancer drugs to predict the emergence of tolerant cells

Co-supervision: Jérémie Roux (Mari Team, IPMC) & Madalena Chaves (BioCore Team, Inria)
IPMC/ Aging Cell Publication
Team Marie-Barik

Age-dependent NMDA receptor function is regulated by the amyloid precursor protein
IPMC/ Brain Publication
Mantegazza's Team

The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications.

Link to publication...
Link to Inserm..

New publication Science Advances
Team Marie-Barik
IPMC/ Classement mondial Expertscape
During Sudden Cardiac Arrest Awareness Month (October 2021), we congratulate
Dr. Massimo Mantegazza of the Centre National de la Recherche Scientifique --
Recognized as an Expertscape Expert in NAV1.1 Voltage-Gated Sodium Channels.,+M

Cortical Spreading Depolarization (CSD), a wave of neuronal hyperexcitability followed by a sudden drop in activity, is a pathological mechanism of migraine with aura and of other neurological diseases. M.Mantegazza’s group has studied the mechanism of CSD initiation induced by gain-of-function mutations of the NaV1.1 sodium channel, implicated in "familial hemiplegic migraine ". The group has shown that CSD is triggered specifically in the cortex by hyperexcitation of GABAergic neurons and this mechanism depends  on the increase of extracellular potassium concentration, resulting from the pathological excitation of neurons induced by the gain of function of NaV1.1
IPMC/ World Alzheimer's Day 21/09
Dr Frédéric CHECLER, Inserm Research Director and team leader at the IPMC, is interviewed by France 3 Côte-d'Azur for his expertise on Alzheimer's disease.
IPMC/ Expertscape World Ranking
As part of World Alzheimer's Day (Sep 21, 2021), Dr. Frédéric Checler, Inserm research director,  recognized as an Expertscape World Expert in Amyloid Precursor Protein Secretases.

Publication IPMC/ Lancet Regional Health Europe
The Promenade niçoise of the English variant

This article details the spread of the "English" (alpha) variant of SARS-CoV-2 within the city of Nice in early 2021. Dr. Pascal Barbry's team analyzed wastewater from about 20 points in the city by RNA sequencing. This allowed them to map the composition of different variants present in the territory. Such approaches may provide valuable epidemiological information in the future.
Publication IPMC/Neurosciences
Identification of a new role of XBP1 in the control of mitophagy and potential impact to the etiology of Parkinson’s disease

Parkinson’s disease (PD) is characterized by an exacerbated endoplasmic reticulum stress and by mitophagy defects. The molecular triggers linking these two alterations had not been yet described. We have shown that XBP1s controlled the transcription of PINK1, a master regulator of mitophagy, and that PINK1 modulated XBP1S phosphorylation, subcellular localization and function. We established that this functional interplay impacted mitophagy process in several PD cellular and mice models as well as in PD-affected brains.

Publication IPMC/ Biochimie
What do secreted phospholipases A2 have to offer in the fight against various viruses up to SARS-CoV-2?

Secreted phospholipases A2 (sPLA2) have antimicrobial properties against different bacteria, but also against different viruses and parasites such as Plasmodium falciparum (malaria). This review, written by two teams with expertise in venom and human sPLA2, summarises our knowledge of the antiviral and proviral role of sPLA2, illustrating their potential role as a therapeutic target, biologically active molecule or biomarker of viral infections, up to and including the SARS-CoV-2 virus, responsible for the Covid-19 pandemic.
Recipients of Alpes Maritimes Department's Health 2020 call
Three IPMC equipment projects have been awarded a prize in the Alpes Maritimes Department's Health 2020 call. Remarkably, IPMC is the only academic research laboratory to be distinguished. The prizes were given on 27 May in the Hemicycle of the Hôtel du Département des Alpes-Maritimes.

Publication IPMC/ Cell Metabolism
Breast Cancer: The flip side of strength
Breast cancer remains the 2nd leading cause of cancer death in women, despite existing therapies. In this study, Thomas Bertero & Stéphanie Torrino have identified one of the molecular and cellular mechanisms that promote the development of these cancers. Their results open new therapeutic perspectives for breast cancer but also for other pathologies.




 Sanchez C. et al. (2024). Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain Behav Immun

 Fotso C.T. et al. (2024). A mixture-like model for tumor-immune system interactions. J Theor Biol

 Delhaye S. et al. (2023). Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a. Neurobiol Dis

 Bauer C. et al. (2023). Potentially Pathogenic SORL1 Mutations Observed in Autosomal-Dominant Cases of Alzheimer's Disease Do Not Modulate APP Physiopathological Processing. Cells

 Kovcs D. et al. (2024). Lipid exchange at ER-trans-Golgi contact sites governs polarized cargo sorting. J Cell Biol

 Smith J. et al. (2023). Are we there yet ? : A critical evaluation of SUDEP models. Epilepsia

 Battivelli D. et al. (2023). Dopamine neuron activity and stress signalling as links between social hierarchy and psychopathology vulnerability. Biol Psychiatry

 Jzquel G. et al. (2023). Structure-Based Design of a Lead Compound Derived from Natural Schweinfurthins with Antitumor Properties That Target Oxysterol-Binding Protein. J Med Chem


Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03

Conférences à venir

Le 2 février 2024 à 11h00
F.Luton invite le Pr. Rachel Lennon
"Defining basement membranes - parts, diversity and diease"