IPMC/ Aging Cell Publication
Team Marie-Barik
Age-dependent NMDA receptor function is regulated by the amyloid precursor protein
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IPMC/ Brain Publication
Mantegazza's TeamThe gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications. Link to publication...
Link to Inserm..
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New publication Science Advances
Team Marie-Barik
https://www-science-org.insb.bib.cnrs.fr/doi/10.1126/sciadv.abg5970
IPMC/ Classement mondial Expertscape
During Sudden Cardiac Arrest Awareness Month (October 2021), we congratulate Dr. Massimo Mantegazza of the Centre National de la Recherche Scientifique --
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| IPMC/PUBLICATION JCI Team Mantegazza Cortical Spreading Depolarization (CSD), a wave of neuronal hyperexcitability followed by a sudden drop in activity, is a pathological mechanism of migraine with aura and of other neurological diseases. M.Mantegazza’s group has studied the mechanism of CSD initiation induced by gain-of-function mutations of the NaV1.1 sodium channel, implicated in "familial hemiplegic migraine ". The group has shown that CSD is triggered specifically in the cortex by hyperexcitation of GABAergic neurons and this mechanism depends on the increase of extracellular potassium concentration, resulting from the pathological excitation of neurons induced by the gain of function of NaV1.1 https://www.jci.org/articles/view/142203
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IPMC/ World Alzheimer's Day 21/09
Dr Frédéric CHECLER, Inserm Research Director and team leader at the IPMC, is interviewed by France 3 Côte-d'Azur for his expertise on Alzheimer's disease. |
IPMC/ Expertscape World Ranking
As part of World Alzheimer's Day (Sep 21, 2021), Dr. Frédéric Checler, Inserm research director, recognized as an Expertscape World Expert in Amyloid Precursor Protein Secretases.
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| Publication IPMC/ Lancet Regional Health Europe The Promenade niçoise of the English variant
This article details the spread of the "English" (alpha) variant of SARS-CoV-2 within the city of Nice in early 2021. Dr. Pascal Barbry's team analyzed wastewater from about 20 points in the city by RNA sequencing. This allowed them to map the composition of different variants present in the territory. Such approaches may provide valuable epidemiological information in the future.
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Publication IPMC/Neurosciences
Identification of a new role of XBP1 in the control of mitophagy and potential impact to the etiology of Parkinson’s disease
Parkinson’s disease (PD) is characterized by an exacerbated endoplasmic reticulum stress and by mitophagy defects. The molecular triggers linking these two alterations had not been yet described. We have shown that XBP1s controlled the transcription of PINK1, a master regulator of mitophagy, and that PINK1 modulated XBP1S phosphorylation, subcellular localization and function. We established that this functional interplay impacted mitophagy process in several PD cellular and mice models as well as in PD-affected brains.
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Publication IPMC/ Biochimie
What do secreted phospholipases A2 have to offer in the fight against various viruses up to SARS-CoV-2?
Secreted phospholipases A2 (sPLA2) have antimicrobial properties against different bacteria, but also against different viruses and parasites such as Plasmodium falciparum (malaria). This review, written by two teams with expertise in venom and human sPLA2, summarises our knowledge of the antiviral and proviral role of sPLA2, illustrating their potential role as a therapeutic target, biologically active molecule or biomarker of viral infections, up to and including the SARS-CoV-2 virus, responsible for the Covid-19 pandemic.
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Recipients of Alpes Maritimes Department's Health 2020 call
Three IPMC equipment projects have been awarded a prize in the Alpes Maritimes Department's Health 2020 call. Remarkably, IPMC is the only academic research laboratory to be distinguished. The prizes were given on 27 May in the Hemicycle of the Hôtel du Département des Alpes-Maritimes.
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Publication IPMC/ Cell Metabolism
Breast Cancer: The flip side of strength Breast cancer remains the 2nd leading cause of cancer death in women, despite existing therapies. In this study, Thomas Bertero & Stéphanie Torrino have identified one of the molecular and cellular mechanisms that promote the development of these cancers. Their results open new therapeutic perspectives for breast cancer but also for other pathologies.
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