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Publication IPMC/Neurosciences
Identification of a new role of XBP1 in the control of mitophagy and potential impact to the etiology of Parkinson’s disease

Parkinson’s disease (PD) is characterized by an exacerbated endoplasmic reticulum stress and by mitophagy defects. The molecular triggers linking these two alterations had not been yet described. We have shown that XBP1s controlled the transcription of PINK1, a master regulator of mitophagy, and that PINK1 modulated XBP1S phosphorylation, subcellular localization and function. We established that this functional interplay impacted mitophagy process in several PD cellular and mice models as well as in PD-affected brains.

Publication IPMC/ Biochimie
What do secreted phospholipases A2 have to offer in the fight against various viruses up to SARS-CoV-2?

Secreted phospholipases A2 (sPLA2) have antimicrobial properties against different bacteria, but also against different viruses and parasites such as Plasmodium falciparum (malaria). This review, written by two teams with expertise in venom and human sPLA2, summarises our knowledge of the antiviral and proviral role of sPLA2, illustrating their potential role as a therapeutic target, biologically active molecule or biomarker of viral infections, up to and including the SARS-CoV-2 virus, responsible for the Covid-19 pandemic.
Recipients of Alpes Maritimes Department's Health 2020 call
Three IPMC equipment projects have been awarded a prize in the Alpes Maritimes Department's Health 2020 call. Remarkably, IPMC is the only academic research laboratory to be distinguished. The prizes were given on 27 May in the Hemicycle of the Hôtel du Département des Alpes-Maritimes.

Publication IPMC/ Cell Metabolism
Breast Cancer: The flip side of strength
Breast cancer remains the 2nd leading cause of cancer death in women, despite existing therapies. In this study, Thomas Bertero & Stéphanie Torrino have identified one of the molecular and cellular mechanisms that promote the development of these cancers. Their results open new therapeutic perspectives for breast cancer but also for other pathologies.

IPMC/ Neuroplanète 2021
On 28 & 29 May, the Centre Universitaire Méditerranéen hosted the 6th edition of Neuroplanète, the forum dedicated to the brain organised by Le Point in partnership with the city of Nice.
The conference "Why and how eating well makes you happy" was led by Pierre-Marie Lledo (CNRS, Institut Pasteur), Carole Rovere (Inserm, IPMC) and Pr Stéphane Schneider (CHU Nice).
Publication IPMC/ Frontiers in Immunology
On 16 April 2021, the work of Aïda Meghraoui-Kheddar, from the team of Fabienne Anjuère and Véronique Braud, was published in the scientific journal Frontiers in Immunology.
This publication deals with the integrative analysis of the components of the tumour immune microenvironment, their interactions and their micro-anatomical distribution.
Publication IPMC/ Journal of Investigative Dermatology
Study on cutaneous squamous cell carcinomas
Scientists from the IPMC (CNRS-Université Côte d'Azur), including Fabienne Anjuere, Inserm research fellow, and Véronique Braud, CNRS research director, have just published a study on cutaneous squamous cell carcinomas in the Journal of Investigative Dermatology.

The IPMC in China!
The CNRS Office in China represents the Europe of Research and International Cooperation Department (DERCI) locally and contributes to the local promotion of CNRS.
On the occasion of the 33rd edition of the magazine "CNRS in China", an article presents the project led by Malika Arhatte (Research Engineer, UCA) working in the team of Dr Eric Honoré (Director of Research, CNRS). A research project on obesity in collaboration with the laboratory of Prof. Aimin XU, at the University of Hong Kong.

Publication IPMC/ Acta Neuropathologica
Identification of an early marker in Alzheimer's disease
Scientists from the IPMC (CNRS-Université Côte d'Azur) in the team of Frédéric Checler, Inserm research director, have just published a scientific article on the identification of an early marker in Alzheimer's disease in the journal Acta Neuropathologica.
The authors highlight a new avenue for better understanding the appearance and progression of amyloid peptides.

Publication IPMC/ Nature Communications
A protective gene for aggressive forms of breast cancer

In a study published in Nature Communications, the team of Michel Franco (DR CNRS) & Frédéric Luton (DR Inserm) has identified a protective gene for aggressive forms of breast cancer. The work concerns the identification and characterisation of a protein that plays a key role in controlling the invasive properties of tumour cells.
Gérard Lambeau/ Prix Jean Valade
Fondation de France
Gérard LAMBEAU, team leader at the IPMC, is a senior laureate of the Jean Valade Foundation for his project "Revolution in the medical follow-up of glomerulonephritis".

Publication IPMC/ Nature Communications
Understanding the impact of the FMR1 gene in fragile X syndrome
Stéphane Martin's team, Inserm Research Director at the Institute of Molecular and Cellular Pharmacology (IPMC - Université Côte d'Azur / CNRS), has published a study in the journal Nature Communications showing that induction of a mutation in the FMR1 gene in mice, which is known to be involved in Fragile X syndrome in humans, causes deterioration in neuronal communication and socio-cognitive deficits.



PhD student (M/F): Study of the role of parkin in the pathophysiology of Alzheimer's disease

PhD student (M/F): Study of the physiopathological role of PE, an endogenous inhibitor of TREK-1 channel

PhD student (M/F): Rescue of Nav1.2/SCN2A sodium channel in neurodevelopmental disorders: Electrophysiology (in vivo/ex vivo/in vitro) and behaviour



 Delfosse V. et al. (2020). Structural and Functional Specialization of OSBP-Related Proteins Contact

 Valverde A. et al. (2021). Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains. J Biol Chem

 Bermudez-Martin P. et al. (2021). The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota. Microbiome

 Dacheux M. et al. (2021). Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model. Biochimie

 Logt A.V. et al. (2021). Anti-PLA2R1 Antibodies as Prognostic Biomarker in Membranous Nephropathy. Kidney Int Rep

 de la Mora E. et al. (2021). Nanoscale architecture of a VAP-A-OSBP tethering complex at membrane contact sites. Nat Commun

 Pungercar J. et al. (2021). What do secreted phospholipases A(2) have to offer in combat against different viruses up to SARS-CoV-2? Biochimie

 Alari V. et al. (2021). Histone Deacetylase Inhibitors Ameliorate Morphological Defects and Hypoexcitability of iPSC-Neurons from Rubinstein-Taybi Patients. Int J Mol Sci

Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
660 Route des Lucioles

tél : 04 93 95 77 77 - fax : 04 93 95 77 08


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