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IPMC/ Aging Cell Publication
Team Marie-Barik

Age-dependent NMDA receptor function is regulated by the amyloid precursor protein
IPMC/ Brain Publication
Mantegazza's Team

The gain of function SCN1A disorder spectrum: novel epilepsy phenotypes and therapeutic implications.

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New publication Science Advances
Team Marie-Barik
IPMC/ Classement mondial Expertscape
During Sudden Cardiac Arrest Awareness Month (October 2021), we congratulate
Dr. Massimo Mantegazza of the Centre National de la Recherche Scientifique --
Recognized as an Expertscape Expert in NAV1.1 Voltage-Gated Sodium Channels.,+M

Cortical Spreading Depolarization (CSD), a wave of neuronal hyperexcitability followed by a sudden drop in activity, is a pathological mechanism of migraine with aura and of other neurological diseases. M.Mantegazza’s group has studied the mechanism of CSD initiation induced by gain-of-function mutations of the NaV1.1 sodium channel, implicated in "familial hemiplegic migraine ". The group has shown that CSD is triggered specifically in the cortex by hyperexcitation of GABAergic neurons and this mechanism depends  on the increase of extracellular potassium concentration, resulting from the pathological excitation of neurons induced by the gain of function of NaV1.1
IPMC/ World Alzheimer's Day 21/09
Dr Frédéric CHECLER, Inserm Research Director and team leader at the IPMC, is interviewed by France 3 Côte-d'Azur for his expertise on Alzheimer's disease.
IPMC/ Expertscape World Ranking
As part of World Alzheimer's Day (Sep 21, 2021), Dr. Frédéric Checler, Inserm research director,  recognized as an Expertscape World Expert in Amyloid Precursor Protein Secretases.

Publication IPMC/ Lancet Regional Health Europe
The Promenade niçoise of the English variant

This article details the spread of the "English" (alpha) variant of SARS-CoV-2 within the city of Nice in early 2021. Dr. Pascal Barbry's team analyzed wastewater from about 20 points in the city by RNA sequencing. This allowed them to map the composition of different variants present in the territory. Such approaches may provide valuable epidemiological information in the future.
Publication IPMC/Neurosciences
Identification of a new role of XBP1 in the control of mitophagy and potential impact to the etiology of Parkinson’s disease

Parkinson’s disease (PD) is characterized by an exacerbated endoplasmic reticulum stress and by mitophagy defects. The molecular triggers linking these two alterations had not been yet described. We have shown that XBP1s controlled the transcription of PINK1, a master regulator of mitophagy, and that PINK1 modulated XBP1S phosphorylation, subcellular localization and function. We established that this functional interplay impacted mitophagy process in several PD cellular and mice models as well as in PD-affected brains.

Publication IPMC/ Biochimie
What do secreted phospholipases A2 have to offer in the fight against various viruses up to SARS-CoV-2?

Secreted phospholipases A2 (sPLA2) have antimicrobial properties against different bacteria, but also against different viruses and parasites such as Plasmodium falciparum (malaria). This review, written by two teams with expertise in venom and human sPLA2, summarises our knowledge of the antiviral and proviral role of sPLA2, illustrating their potential role as a therapeutic target, biologically active molecule or biomarker of viral infections, up to and including the SARS-CoV-2 virus, responsible for the Covid-19 pandemic.
Recipients of Alpes Maritimes Department's Health 2020 call
Three IPMC equipment projects have been awarded a prize in the Alpes Maritimes Department's Health 2020 call. Remarkably, IPMC is the only academic research laboratory to be distinguished. The prizes were given on 27 May in the Hemicycle of the Hôtel du Département des Alpes-Maritimes.

Publication IPMC/ Cell Metabolism
Breast Cancer: The flip side of strength
Breast cancer remains the 2nd leading cause of cancer death in women, despite existing therapies. In this study, Thomas Bertero & Stéphanie Torrino have identified one of the molecular and cellular mechanisms that promote the development of these cancers. Their results open new therapeutic perspectives for breast cancer but also for other pathologies.




 Tempio A. et al. (2023). Fragile X Syndrome as an interneuronopathy: a lesson for future studies and treatments. Front Neurosci

 Lemaire L. et al. (2023). Idealized multiple-timescale model of cortical spreading depolarization initiation and pre-epileptic hyperexcitability caused by Na(V)1.1/SCN1A mutations. J Math Biol

 Chafa M. et al. (2023). Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling. PLoS Comput Biol

 Barthe M. et al. (2023). Receptors and Cofactors That Contribute to SARS-CoV-2 Entry: Can Skin Be an Alternative Route of Entry? Int J Mol Sci

 Landra-Willm A. et al. (2023). A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals. Nat Commun

 Khoury S. et al. (2023). Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases. Biomolecules

 Subra M. et al. (2023). VAP-A intrinsically disordered regions enable versatile tethering at membrane contact sites. Dev Cell

 Bihl F. and Lambeau G. et al. (2023). Toward a bona fide animal model of PLA2R1-associated membranous nephropathy: one step forward. Kidney Int

Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
Friday, June 9th 2023 at 11: AM : :
Mounia CHAMI invite le Pr. Michael DUCHEN -Department of Cell and Developmental Biology, University College LONDON :
Cross talk between autophagy and mitochondrial function; shaping the presentation and progression of mitochondrial disease

Thursday, July 6th 2023 at 11: AM : :
Hlne MARIE invite le Dr David Blum - Lille Neuroscience and Cognition Research Center, Universit de Lille. :
"The Neuroglial basis of caffeine effects in the Alzheimer's disease brain"

Tuesday, July 11th 2023 at 2: PM : :
Thse soutenue par Aurore Bernardin (dir. Dr. Cristine Alves da Costa) :
"Rle de la Parkine dans la propagation tumorale lie la gliomagense, tudes translationnelles in vitro et in vivo"

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