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IPMC/ Sophia Mag/ Behavioural disorders: it’s not all in themind

In an immunology laboratory in Sophia Antipolis, «psychiatry» is spelt “psych-AItry». Why are immunologists joining up with psychiatrists, and what is more, accompanied by Artificial Intelligence? Susana Barbosa works in Nicolas Glaichenhaus’ team at the Institut de Pharmacologie Moléculaire et Cellulaire. The team is entitled “Immune system, brain and peripheral nerves” and aims, among other things, at identifying immune biomarkers in blood with the intent to better diagnose mental illness.
Publication Cell Reports 2020
You've just finished a good meal and you feel full? Researchers from the CNRS, Inrae, the University of Burgundy, the University of Paris, Inserm and the University of Luxembourg have just understood the mechanisms in your brain that led to this state. It is a cascade of reactions triggered by an increase in blood glucose levels. This study, conducted in mice, is published in Cell Reports on March 3, 2020.

IPMC / Publication The Journal of Clinical Investigation
Gérard Lambeau, chercheur CNRS à l'IPMC
(CNRS - Université Côte d'Azur)

IPMC/ Publication of a scientific article in Nature Communications

The team of Florian Lesage, an Inserm researcher at the Institut de Pharmacologie Moléculaire et Cellulaire (CNRS-Université Côte d'Azur), has identified a new therapeutic approach to treat certain neurodevelopmental diseases, in particular Birk Barel syndrome. This work was published in Nature Communications :"Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome"

Florian Lesage, an Inserm researcher at IPMC (CNRS - Université Côte d'Azur)

IPMC / Marie Curie Fellowship Awarded
Aurore Thomazeau, currently a researcher in neuroscience at McGill University in Montreal, has just been awarded an individual "Marie Sklodowska-Curie Actions Global Fellowship" with the METAFRAX project (Unconventional NMDAR signaling theory for Fragile X Syndrome). She will join the team RNA Metabolism and Diseases related to Neurodevelopment of Dr Barbara Bardoni, DR Inserm at IPMC (CNRS-University Côte d'Azur).

Visit of the laboratory by CIV college students

A "Science Professions" morning was organized by Anne Baron, CNRS research fellow at the IPMC in Sophia-Antipolis on Thursday, January 30. The 30 students from a 4th year class at the Centre International de Valbonne were able to attend presentations by scientists and visit the laboratory's imaging, histology, proteomics and lipidomics platforms.

Visit of the laboratory by students from Antibes

A "Science Professions" afternoon was organized this Tuesday, January 21 at the Institute of Molecular and Cellular Pharmacology in Sophia-Antipolis for high school students from the Lycée Horticole Vert d'Azur. A visit to the laboratory's cytometry and imaging platforms was proposed to them to close the visit.
Ceremony to award medals to the three CNRS Talents 2019

The CNRS Talent Medals were awarded on Tuesday 10 December 2019 at the Mediterranean University Centre in Nice. Among the 3 laureates are 2 IPMC researchers, Jacques BARIK and Thomas BERTERO, recipients of the Bronze Medal.

Symposium UCAncer
June 15 & 16 2020 - Inria, Sophia Antipolis

Multidisciplinary Approaches in Cancer Research
For our Institute, 2018 marks the beginning of a new five-year contract marked by renewed support from the CNRS and the University Nice Sophia Antipolis. On this occasion, the leadership has changed but not the objectives desired by its founder: to seek and discover and to advance knowledge by a research to the highest international levels and to diffuse this by teaching and communication at scientific seminars and public conferences.

The IPMC is multi-thematic, which is a strength, provided that its development is based on structuring choices that favor the collaboration between existing teams and the recruitment of new teams, able to strengthen the internal potential. This assumes thematic choices and a structuring of the teams in axes sharing common interests centered on Molecular and Cellular Pharmacology, our core business, but integrating the most recent developments in "omics", cellular imaging and integrated life studies.

In addition, the communication policy must be designed to increase the visibility of the IPMC and maintain its funding and attractiveness towards students, researchers, engineers and technicians. The modes of research funding continue to evolve as local and regional structures become increasingly important. The IPMC must maintain its international visibility while being a major player in local scientific and university development, in particular IDEX led by the University Côte D'Azur. In this way, connections with major foreign universities, in Canada and in China in particular, are in progress in order to sustainably integrate IPMC into an international network of excellence.

Our Institute will be 30 years old next year. It's still young, younger than most of us, but the maturity is here with an already long list of major breakthroughs and innovations, built with determination by all who participated in this demanding adventure. In essence, scientific research knows neither frontiers nor boundaries, and the IPMC is not an “ivory tower”. Each year students are trained within it, and many of these former students have spread throughout France and abroad to pursue research in the public and private sectors.

To change, to renew oneself to progress, what could be more exciting for the years to come?
 Chami M. and Checler F. et al. (2020). Targeting Post-Translational Remodeling of Ryanodine Receptor: a New Track for Alzheimer's Disease Therapy? Curr Alzheimer Res

 Peresse T. et al. (2020). Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor. J Biol Chem

 Goncalves-Maia M. et al. (2020). NK cell and fibroblast-mediated regulation of skin squamous cell carcinoma invasion by CLEC2A is compromised in Xeroderma Pigmentosum. J Invest Dermatol

 Atsou K. et al. (2020). A size and space structured model describing interactions of tumor cells with immune cells reveals cancer persistent equilibrium states in tumorigenesis. J Theor Biol

 Cooper A. et al. (2020). Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nat Commun

 Sicard A. et al. (2020). Donor-specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients. Am J Transplant

 Zerimech S. et al. (2020). Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive. Neuropharmacology

 Barbosa S. et al. (2020). Serum cytokines associated with behavior: a cross-sectional study in 5-year-old children. Brain Behav Immun

Interview with Dr. Gérard Lambeau - RCF Radio - program "A votre service" of 12/03
Monday, June 8th 2020 at 2: PM : :
HDR soutenue par Thomas BERTERO :

Friday, June 12th 2020 at 11: AM : :
Stphane MARTIN invite le Dr. Michela MATTEOLI (Keynote Seminar Series) :

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tél : 04 93 95 77 77 - fax : 04 93 95 77 08


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