86   Negm A., Stobbe K., Ben Fradj S., Sanchez C., Landra-Willm A., Richter M., Fleuriot L., Debayle D., Deval E., Lingueglia E., Rovere C. and Noel J. (2024). Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice. Pain, 165 (2) : 470-486

85   Chafai M., Delrocq A., Inquimbert P., Pidoux L., Delanoe K., Toft M., Brau F., Lingueglia E., Veltz R. and Deval E. (2023). Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling. PLoS Comput Biol, 19 (4) : e1010993

84   Khoury S., Colas J., Breuil V., Kosek E., Ahmed A.S., Svensson C.I., Marchand F., Deval E. and Ferreira T. (2023). Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases. Biomolecules, 13 (2) :

83   Pidoux L., Delanoe K., Barbier J., Marchand F., Lingueglia E. and Deval E. (2022). Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity. Front Mol Neurosci, 15 () : 880651

82   Jacquot F., Khoury S., Labrum B., Delanoe K., Pidoux L., Barbier J., Delay L., Bayle A., Aissouni Y., Barriere D.A., Kultima K., Freyhult E., Hugo A., Kosek E., Ahmed A.S., Jurczak A., Lingueglia E., Svensson C.I., Breuil V., Ferreira T., Marchand F. and Deval E. (2022). Lysophosphatidyl-choline 16: 0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3. Pain, () :

81   Jurczak A., Delay L., Barbier J., Simon N., Krock E., Sandor K., Agalave N.M., Rudjito R., Wigerblad G., Rogóż, K., Briat A., Miot-Noirault E., Martinez-Martinez A., Brömme D., Grönwall C., Malmström V., Klareskog L., Khoury S., Ferreira T., Labrum B., Deval E., Jiménez-Andrade J.M., Marchand F. and Svensson C.I. (2021). Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity and ASIC3-dependent sensitization. Pain, () :

80   Ávalos Prado P., Landra-Willm A., Verkest C., Ribera A., Chassot A.A., Baron A. and Sandoz G. (2021). TREK channel activation suppresses migraine pain phenotype. iScience, 24 (9) : 102961

79   Verkest C., Diochot S., Lingueglia E. and Baron A. (2021). C-Jun N-Terminal Kinase Post-Translational Regulation of Pain-Related Acid-Sensing Ion Channels 1b and 3. J Neurosci, 41 (42) : 8673-8685

78   Prieto M., Folci A., Poupon G., Schiavi S., Buzzelli V., Pronot M., François U., Pousinha P., Lattuada N., Abelanet S., Castagnola S., Chafai M., Khayachi A., Gwizdek C., Brau F., Deval E., Francolini M., Bardoni B., Humeau Y., Trezza V. and Martin S. (2021). Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice. Nat Commun, 12 (1) : 1557

77   Salinas M., Kessler P., Douguet D., Sarraf D., Tonali N., Thai R., Servent D. and Lingueglia E. (2021). Mambalgin-1 pain-relieving peptide locks the hinge between α4 and α5 helices to inhibit rat acid-sensing ion channel 1a. Neuropharmacology, 185 () : 108453

76   Verkest C., Häfner S., Ávalos Prado P., Baron A. and Sandoz G. (2021). Migraine and Two-Pore-Domain Potassium Channels. Neuroscientist, 27 (3) : 268-284

75   Marchot P., Diochot S., Popoff M.R. and Benoit E. (2020). Report from the 26th Meeting on Toxinology, "Bioengineering of Toxins", Organized by the French Society of Toxinology (SFET) and Held in Paris, France, 4-5 December 2019. Toxins (Basel), 12 (1) :

74   Castellanos A., Pujol-Coma A., Andres-Bilbe A., Negm A., Callejo G., Soto D., Noel J., Comes N. and Gasull X. (2020). TRESK background K(+) channel deletion selectively uncovers enhanced mechanical and cold sensitivity. J Physiol, 598 (5) : 1017-1038

73   Nicolas S., Zoukimian C., Bosmans F., Montnach J., Diochot S., Cuypers E., De Waard S., Beroud R., Mebs D., Craik D., Boturyn D., Lazdunski M., Tytgat J. and De Waard M. (2019). Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1. Toxins (Basel), 11 (6) :

72   Royal P., Andres-Bilbe A., Avalos Prado P., Verkest C., Wdziekonski B., Schaub S., Baron A., Lesage F., Gasull X., Levitz J. and Sandoz G. (2019). Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron, 101 (2) : 232-245.e6

71   Verkest C., Piquet E., Diochot S., Dauvois M., Lanteri-Minet M., Lingueglia E. and Baron A. (2018). Effects of systemic inhibitors of Acid-Sensing Ion Channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine. Br J Pharmacol, () :

70   Khayachi A., Gwizdek C., Poupon G., Alcor D., Chafai M., Casse F., Maurin T., Prieto M., Folci A., De Graeve F., Castagnola S., Gautier R., Schorova L., Loriol C., Pronot M., Besse F., Brau F., Deval E., Bardoni B. and Martin S. (2018). Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation. Nat Commun, 9 (1) : 757

69   Besson T., Lingueglia E. and Salinas M. (2017). Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ). Neuropharmacology, 125 () : 429-440

68   Aissouni Y., El Guerrab A., Hamieh A.M., Ferrier J., Chalus M., Lemaire D., Gregoire S., Etienne M., Eschalier A., Ardid D., Lingueglia E. and Marchand F. (2017). Acid-Sensing Ion Channel 1a in the amygdala is involved in pain and anxiety-related behaviours associated with arthritis. Sci Rep, 7 () : 43617

67   Devader C., Moreno S., Roulot M., Deval E., Dix T., Morales C.R. and Mazella J. (2016). Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice. Front Neurosci, 10 () : 542

66   Besson T., Debayle D., Diochot S., Salinas M. and Lingueglia E. (2016). Low cost venom extractor based on Arduino((R)) board for electrical venom extraction from arthropods and other small animals. Toxicon, 118 () : 156-61

65   Marra S., Ferru-Clement R., Breuil V., Delaunay A., Christin M., Friend V., Sebille S., Cognard C., Ferreira T., Roux C., Euller-Ziegler L., Noel J., Lingueglia E. and Deval E. (2016). Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids. EMBO J, () :

64   Mourier G., Salinas M., Kessler P., Stura E.A., Leblanc M., Tepshi L., Besson T., Diochot S., Baron A., Douguet D., Lingueglia E. and Servent D. (2016). Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a Inhibition. J Biol Chem, 291 (6) : 2616-29

63   Diochot S., Alloui A., Rodrigues P., Dauvois M., Friend V., Aissouni Y., Eschalier A., Lingueglia E. and Baron A. (2016). Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain. Pain, 157 (3) : 552-9

62   Lolignier S., Bonnet C., Gaudioso C., Noel J., Ruel J., Amsalem M., Ferrier J., Rodat-Despoix L., Bouvier V., Aissouni Y., Prival L., Chapuy E., Padilla F., Eschalier A., Delmas P. and Busserolles J. (2015). The nav1.9 channel is a key determinant of cold pain sensation and cold allodynia. Cell Rep, 11 (7) : 1067-78

61   Lingueglia E. and Lazdunski M. (2015). Acid-Sensing Ion Channels in the nervous system. Neuropharmacology, () :

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58   Francois A., Schuetter N., Laffray S., Sanguesa J., Pizzoccaro A., Dubel S., Mantilleri A., Nargeot J., Noel J., Wood J.N., Moqrich A., Pongs O. and Bourinet E. (2015). The Low-Threshold Calcium Channel Cav3.2 Determines Low-Threshold Mechanoreceptor Function. Cell Rep, () :

57   Loriol C., Casse F., Khayachi A., Poupon G., Chafai M., Deval E., Gwizdek C. and Martin S. (2014). mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines. Nat Commun, 5 () : 5113

56   Pereira V., Busserolles J., Christin M., Devilliers M., Poupon L., Legha W., Alloui A., Aissouni Y., Bourinet E., Lesage F., Eschalier A., Lazdunski M. and Noel J. (2014). Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Pain, () :

55   Lingueglia E. (2014). [Acid-Sensing Ion Channels (ASICs) in pain]. Biol Aujourdhui, 208 (1) : 13-20

54   Salinas M., Besson T., Delettre Q., Diochot S., Boulakirba S., Douguet D. and Lingueglia E. (2014). Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-Relieving Peptide on Acid-Sensing Ion Channel 1a. J Biol Chem, 289 (19) : 13363-73

53   Devilliers M., Busserolles J., Lolignier S., Deval E., Pereira V., Alloui A., Christin M., Mazet B., Delmas P., Noel J., Lazdunski M. and Eschalier A. (2013). Activation of TREK-1 by morphine results in analgesia without adverse side effects. Nat Commun, 4 () : 2941

52   Baron A., Diochot S., Salinas M., Deval E., Noel J. and Lingueglia E. (2013). Venom toxins in the exploration of molecular, physiological and pathophysiological functions of Acid-Sensing Ion Channels. Toxicon, 75 () : 187-204

51   Hao J., Padilla F., Dandonneau M., Lavebratt C., Lesage F., Noel J. and Delmas P. (2013). Kv1.1 channels act as mechanical brake in the senses of touch and pain. Neuron, 77 (5) : 899-914

50   Fromy B., Lingueglia E., Sigaudo-Roussel D., Saumet J.L. and Lazdunski M. (2013). [An ionic channel involved in the skin protection against pressure]. Med Sci (Paris), 29 (2) : 130-2

49   Diochot S., Baron A., Salinas M., Douguet D., Scarzello S., Dabert-Gay A.S., Debayle D., Friend V., Alloui A., Lazdunski M. and Lingueglia E. (2012). Black mamba venom peptides target acid-sensing ion channels to abolish pain. Nature, 490 (7421) : 552-5

48   Fromy B., Lingueglia E., Sigaudo-Roussel D. , Saumet JL. and Lazdunski M. (2012). Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers. Nat Med, 18 () : 1205–07

47   Delaunay A., Gasull X., Salinas M., Noel J., Friend V., Lingueglia E. and Deval E. (2012). Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions Proc Natl Acad Sci U S A, 109 (32) : 13124-9

46   Noel J., Salinas M., Baron A., Diochot S., Deval E. and Lingueglia E. (2010). Current perspectives on acid-sensing ion channels: new advances and therapeutic implications. Expert Rev Clin Pharmacol, 3 (3) : 331-46

45   Noel J., Sandoz G. and Lesage F. (2011). Molecular regulations governing TREK and TRAAK channel functions. Channels (Austin), 5 (5) : 402-9

44   Deval E, Noel J, Gasull X, Delaunay A, Alloui A, Friend V, Eschalier A, Lazdunski M and Lingueglia E (2011). Acid-Sensing Ion Channels in Postoperative Pain. J Neurosci, 31 (16) : 6059-6066

43   Descoeur J., Pereira V., Pizzoccaro A., Francois A., Ling B., Maffre V., Couette B., Busserolles J., Courteix C., Noel J., Lazdunski M., Eschalier A., Authier N. and Bourinet E. (2011). Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med, 3 (5) : 266-78

42   Deval E., Gasull X., Noel J., Salinas M., Baron A., Diochot S. and Lingueglia E. (2010). Acid-Sensing Ion Channels (ASICs): pharmacology and implication in pain. Pharmacol Ther, 128 (3) : 549-58

41   Salinas M. ., Lazdunski M. . and Lingueglia E. . (2009). Structural elements for the generation of sustained currents by the acid pain sensor ASIC3. J Biol Chem , 284 (46) : 31851-9

40   Noel J., Zimmermann K., Busserolles J., Deval E., Alloui A., Diochot S., Guy N., Borsotto M., Reeh P., Eschalier A. and Lazdunski M. (2009). The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception. EMBO J, 28 (9) : 1308-18

39   Lingueglia E. (2008). Acid-Sensing Ion Channels (ASICs) in chronic pain Douleur et Analgésie, 21 (4) : 209-214

38   Deval E. and Lingueglia E. (2008). Les canaux ioniques ASIC : des senseurs de l’acidification extracellulaire dans le système nerveux Biofutur, 294 () : 49-51

37   Ettaiche M. ., Deval E. ., Pagnotta S. ., Lazdunski M. . and Lingueglia E. . (2009). Acid-sensing ion channel 3 in retinal function and survival. Invest Ophthalmol Vis Sci , 50 (5 ) : 2417

36   Deval E., Noel J., Lay N., Alloui A., Diochot S., Friend V., Jodar M., Lazdunski M. and Lingueglia E (2008). ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J , 27 (22 ) : 3047

35   Baron A., Voilley N., Lazdunski M. and Lingueglia E. (2008). Acid sensing ion channels in dorsal spinal cord neurons. J Neurosci, 28 (6) : 1498-508

34   Mazzuca M., Heurteaux C., Alloui A., Diochot S., Baron A., Voilley N., Blondeau N., Escoubas P., Gelot A., Cupo A., Zimmer A., Zimmer A.M., Eschalier A. and Lazdunski M. (2007). A tarantula peptide against pain via ASIC1a channels and opioid mechanisms Nature neuroscience, 10 (8) : 943-45

33   Lingueglia E. (2007). Acid-sensing ion channels in sensory perception. J Biol Chem, 282 (24) : 17325-9

32   Diochot S., Salinas M., Baron A., Escoubas P. and Lazdunski M. (2007). Peptides inhibitors of acid-sensing ion channels. Toxicon, 49 (2) : 271-84

31   Ettaiche M., Deval E., Cougnon M., Lazdunski M. and Voilley N. (2006). Silencing acid-sensing ion channel 1a alters cone-mediated retinal J Neurosci, 26 (21) : 5800-9

30   Lingueglia E., Deval E. and Lazdunski M. (2006). FMRFamide-gated sodium Channel and ASIC Channels: a new class of ionotropic receptors for FMRFamide and related peptides. Peptides, 27 (5) : 1138-52

29   Deval E., Friend V., Thirant C., Salinas M., Jodar M., Lazdunski M. and Lingueglia E. (2006). Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. J Biol Chem, 281 (3) : 1796-807

28   Roza C., Puel J.L., Kress M., Baron A., Diochot S., Lazdunski M. and Waldmann R. (2004). Knockout of the ASIC2 channel in mice does not impair cutaneous J Physiol, 558 (Pt 2) : 659-69

27   Diochot S., Baron A., Rash L.D., Deval E., Escoubas P., Scarzello S., Salinas M. and Lazdunski M. (2004). A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive EMBO J, 23 (7) : 1516-25

26   Deval E., Salinas M., Baron A., Lingueglia E. and Lazdunski M. (2004). ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1 J Biol Chem, 279 (19) : 19531-9

25   Deval E., Baron A., Lingueglia E., Mazarguil H., Zajac J.M. and Lazdunski M. (2003). Effects of neuropeptide SF and related peptides on acid sensing ion Neuropharmacology, 44 (5) : 662-71

24   Baron A., Deval E., Salinas M., Lingueglia E., Voilley N. and Lazdunski M. (2002). Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the J Biol Chem, 277 (52) : 50463-8

23   Anzai N., Deval E., Schaefer L., Friend V., Lazdunski M. and Lingueglia E. (2002). The multivalent PDZ domain-containing protein CIPP is a partner of J Biol Chem, 277 (19) : 16655-61

22   Poet M., Tauc M., Lingueglia E., Cance P., Poujeol P., Lazdunski M. and Counillon L. (2001). Exploration of the pore structure of a peptide-gated Na+ channel. EMBO J, 20 (20) : 5595-602

21   Baron A., Schaefer L., Lingueglia E., Champigny G. and Lazdunski M. (2001). Zn2+ and H+ are coactivators of acid-sensing ion channels. J Biol Chem, 276 (38) : 35361-7

20   Coscoy S., de Weille J., Lingueglia E., Fukuda N., Matthay M., Lazdunski M. and Barbry P. (2000). [Amiloride-sensitive sodium channel in the nephron and its activation by Ann Endocrinol (Paris), 61 (2) : 145-6

19   Schaefer L., Sakai H., Mattei M., Lazdunski M. and Lingueglia E. (2000). Molecular cloning, functional expression and chromosomal localization of FEBS Lett, 471 (2-3) : 205-10

18   Sakai H., Lingueglia E., Champigny G., Mattei M.G. and Lazdunski M. (1999). Cloning and functional expression of a novel degenerin-like Na+ channel J Physiol, 519 Pt 2 () : 323-33

17   Waldmann R., Champigny G., Lingueglia E., De Weille J.R., Heurteaux C. and Lazdunski M. (1999). H(+)-gated cation channels. Ann N Y Acad Sci, 868 () : 67-76

16   Lingueglia E. and (1999). Proton and capsaicin receptors: contribution to the physiology and the physiopathology of pain Douleur et Analgésie, 3 () : 243-249

15   Darboux I., Lingueglia E., Pauron D., Barbry P. and Lazdunski M. (1998). A new member of the amiloride-sensitive sodium channel family in Biochem Biophys Res Commun, 246 (1) : 210-6

14   Darboux I., Lingueglia E., Champigny G., Coscoy S., Barbry P. and Lazdunski M. (1998). dGNaC1, a gonad-specific amiloride-sensitive Na+ channel. J Biol Chem, 273 (16) : 9424-9

13   Coscoy S., Lingueglia E., Lazdunski M. and Barbry P. (1998). The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer. J Biol Chem, 273 (14) : 8317-22

12   Lingueglia E., de Weille J.R., Bassilana F., Heurteaux C., Sakai H., Waldmann R. and Lazdunski M. (1997). A modulatory subunit of acid sensing ion channels in brain and dorsal root J Biol Chem, 272 (47) : 29778-83

11   Voilley N., Galibert A., Bassilana F., Renard S., Lingueglia E., Coscoy S., Champigny G., Hofman P., Lazdunski M. and Barbry P. (1997). The amiloride-sensitive Na+ channel: from primary structure to function. Comp Biochem Physiol A Physiol, 118 (2) : 193-200

10   Barbry P., Champigny G., Lingueglia E., Voilley N., Waldmann R. and Lazdunski M. (1996). [The amiloride sensitive sodium channel] Nephrologie, 17 (7) : 389-93

9   Lingueglia E., Voilley N., Lazdunski M. and Barbry P. (1996). Molecular biology of the amiloride-sensitive epithelial Na+ channel. Exp Physiol, 81 (3) : 483-92

8   Lingueglia E., Voilley N., Waldmann R., Lazdunski M. and Barbry P. (1993). Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new FEBS Lett, 318 (1) : 95-9

7   Lingueglia E., Renard S., Voilley N., Waldmann R., Chassande O., Lazdunski M. and Barbry P. (1993). Molecular cloning and functional expression of different molecular forms Eur J Biochem, 216 (2) : 679-87

6   Voilley N., Lingueglia E., Champigny G., Mattei M.G., Waldmann R., Lazdunski M. and Barbry P. (1994). The lung amiloride-sensitive Na+ channel: biophysical properties, Proc Natl Acad Sci U S A, 91 (1) : 247-51

5   Lingueglia E., Renard S., Waldmann R., Voilley N., Champigny G., Plass H., Lazdunski M. and Barbry P. (1994). Different homologous subunits of the amiloride-sensitive Na+ channel are J Biol Chem, 269 (19) : 13736-9

4   Champigny G., Voilley N., Lingueglia E., Friend V., Barbry P. and Lazdunski M. (1994). Regulation of expression of the lung amiloride-sensitive Na+ channel by EMBO J, 13 (9) : 2177-81

3   Renard S., Lingueglia E., Voilley N., Lazdunski M. and Barbry P. (1994). Biochemical analysis of the membrane topology of the amiloride-sensitive J Biol Chem, 269 (17) : 12981-6

2   Lingueglia E., Champigny G., Lazdunski M. and Barbry P. (1995). Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature, 378 (6558) : 730-3

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