142 
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Clin Transl Med, 13 (5) : e1266
141 Alameh M., Oliveira-Mendes B.R., Kyndt F., Rivron J., Denjoy I., Lesage F., Schott J.J., De Waard M. and Loussouarn G. (2023). A need for exhaustive and standardized characterization of ion channels activity. The case of K(V)11.1.
Front Physiol, 14 () : 1132533
140 Landra-Willm A., Karapurkar A., Duveau A., Chassot A.A., Esnault L., Callejo G., Bied M., Häfner S., Lesage F., Wdziekonski B., Baron A., Fossat P., Marsollier L., Gasull X., Boué-Grabot E., Kienzler M.A. and Sandoz G. (2023). A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals.
Nat Commun, 14 (1) : 1160
139 Khoubza L., Gilbert N., Kim E.J., Chatelain F.C., Feliciangeli S., Abelanet S., Kang D., Lesage F. and Bichet D. (2022). Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells.
J Biol Chem, () : 102447
138 Glogowska E., Arhatte M., Chatelain F.C., Lesage F., Xu A., Grashoff C., Discher D.E., Patel A., Honoré and E. (2021). Piezo1 and Piezo2 foster mechanical gating of K(2P) channels.
Cell Rep, 37 (9) : 110070
137 Oliveira-Mendes B., Feliciangeli S., Mé,nard M., Chatelain F., Alameh M., Montnach J., Nicolas S., Ollivier B., Barc J., Baró, I., Schott J.J., Probst V., Kyndt F., Denjoy I., Lesage F., Loussouarn G. and De Waard M. (2021). A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity.
Clin Transl Med, 11 (11) : e609
136 Choveau F.S., Ben Soussia I., Bichet D., Franck C.C., Feliciangeli S. and Lesage F. (2021). Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels.
Front Pharmacol, 12 () : 755826
135 Khoubza L., Chatelain F.C., Feliciangeli S., Lesage F. and Bichet D. (2021). Physiological roles of heteromerization: focus on the two-pore domain potassium channels.
J Physiol, 599 (4) : 1041-1055
134 Busserolles J., Ben Soussia I., Pouchol L., Marie N., Meleine M., Devilliers M., Judon C., Schopp J., Clé,menceau L., Poupon L., Chapuy E., Richard S., Noble F., Lesage F., Ducki S., Eschalier A. and Lolignier S. (2020). TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects.
Br J Pharmacol, 177 (20) : 4782-4795
133 Cooper A., Butto T., Hammer N., Jagannath S., Fend-Guella D.L., Akhtar J., Radyushkin K., Lesage F., Winter J., Strand S., Roeper J., Zechner U. and Schweiger S. (2020). Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.
Nat Commun, 11 (1) : 480
132 Nematian-Ardestani E., Abd-Wahab F., Chatelain F.C., Sun H., Schewe M., Baukrowitz T. and Tucker S.J. (2020). Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K(+) channel.
J Biol Chem, 295 (2) : 610-618
131 Ben Soussia I., El Mouridi S., Kang D., Leclercq-Blondel A., Khoubza L., Tardy P., Zariohi N., Gendrel M., Lesage F., Kim E.J., Bichet D., Andrini O. and Boulin T. (2019). Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels.
Nat Commun, 10 (1) : 787
130 Royal P., Andres-Bilbe A., Á,valos Prado P., Verkest C., Wdziekonski B., Schaub S., Baron A., Lesage F., Gasull X., Levitz J. and Sandoz G. (2019). Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.
Neuron, 101 (2) : 232-245.e6
129 Soussia I.B., Choveau F.S., Blin S., Kim E.J., Feliciangeli S., Chatelain F.C., Kang D., Bichet D. and Lesage F. (2018). Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels.
Front Mol Neurosci, 11 () : 301
128 Inoue M., Matsuoka H., Lesage F. and Harada K. (2019). Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells.
FASEB J, 33 (1) : 455-468
127 Schwingshackl A., Lopez B., Teng B., Luellen C., Lesage F., Belperio J., Olcese R. and Waters C.M. (2017). Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.
Am J Physiol Lung Cell Mol Physiol, 313 (6) : L1030-L1046
126 Buehler P.K., Bleiler D., Tegtmeier I., Heitzmann D., Both C., Georgieff M., Lesage F., Warth R. and Thomas J. (2017). Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.
Respir Physiol Neurobiol, 244 () : 17-25
125 Bobak N., Feliciangeli S., Chen C.C., Ben Soussia I., Bittner S., Pagnotta S., Ruck T., Biel M., Wahl-Schott C., Grimm C., Meuth S.G. and Lesage F. (2017). Recombinant tandem of pore-domains in a Weakly Inward rectifying K(+) channel 2 (TWIK2) forms active lysosomal channels.
Sci Rep, 7 (1) : 649
124 Vivier D., Soussia I.B., Rodrigues N., Lolignier S., Devilliers M., Chatelain F.C., Prival L., Chapuy E., Bourdier G., Bennis K., Lesage F., Eschalier A., Busserolles J. and Ducki S. (2017). Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.
J Med Chem, 60 (3) : 1076-1088
123 Christensen A.H., Chatelain F.C., Huttner I.G., Olesen M.S., Soka M., Feliciangeli S., Horvat C., Santiago C.F., Vandenberg J.I., Schmitt N., Olesen S.P., Lesage F. and Fatkin D. (2016). The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.
J Mol Cell Cardiol, 97 () : 24-35
122 Ronjat M., Feng W., Dardevet L., Dong Y., Al Khoury S., Chatelain F.C., Vialla V., Chahboun S., Lesage F., Darbon H., Pessah I.N. and De Waard M. (2016). In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide.
Proc Natl Acad Sci U S A, 113 (17) : E2460-8
121 Blin S., Ben Soussia I., Kim E.J., Brau F., Kang D., Lesage F. and Bichet D. (2016). Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.
Proc Natl Acad Sci U S A, 113 (15) : 4200-5
120 Vivier D., Bennis K., Lesage F. and Ducki S. (2016). Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
J Med Chem, 59 (11) : 5149-57
119 Feliciangeli S., Chatelain F.C., Bichet D. and Lesage F. (2015). The family of K2P channels: salient structural and functional properties.
J Physiol, 593 (12) : 2587-603
118 Bichet D., Blin S., Feliciangeli S., Chatelain F.C., Bobak N. and Lesage F. (2015). Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.
Pflugers Arch, 467 (5) : 1121-31
117 Pereira V., Busserolles J., Christin M., Devilliers M., Poupon L., Legha W., Alloui A., Aissouni Y., Bourinet E., Lesage F., Eschalier A., Lazdunski M. and Noel J. (2014). Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.
Pain, 155 (12) : 2534-44
116 Comoglio Y., Levitz J., Kienzler M.A., Lesage F., Isacoff E.Y. and Sandoz G. (2014). Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.
Proc Natl Acad Sci U S A, 111 (37) : 13547-52
115 Blin S., Chatelain F.C., Feliciangeli S., Kang D., Lesage F. and Bichet D. (2014). Tandem Pore Domain Halothane-inhibited K+ Channel Subunits THIK1 and THIK2 Assemble and Form Active Channels.
J Biol Chem, 289 (41) : 28202-12
114 Bagriantsev S.N., Chatelain F.C., Clark K.A., Alagem N., Reuveny E. and Minor DL J.r. (2014). Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries.
ACS Chem Neurosci, 5 (9) : 812-22
113 Chen H., Chatelain F.C. and Lesage F. (2014). Altered and dynamic ion selectivity of K+ channels in cell development and excitability.
Trends Pharmacol Sci, 35 (9) : 461-9
112 Xiao Z., Cilz N.I., Kurada L., Hu B., Yang C., Wada E., Combs C.K., Porter J.E., Lesage F. and Lei S. (2014). Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model.
J Neurosci, 34 (20) : 7027-42
111 Rodrigues N., Bennis K., Vivier D., Pereira V., C Chatelain F., Chapuy E., Deokar H., Busserolles J., Lesage F., Eschalier A. and Ducki S. (2014). Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.
Eur J Med Chem, 75 () : 391-402
110 Wang W., Putra A., Schools G.P., Ma B., Chen H., Kaczmarek L.K., Barhanin J., Lesage F. and Zhou M. (2013). The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.
Front Cell Neurosci, 7 () : 246
109 Chatelain F.C., Bichet D., Feliciangeli S., Larroque M.M., Braud V.M., Douguet D. and Lesage F. (2013). Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.
J Biol Chem, 288 (49) : 35081-92
108 Wang S., Benamer N., Zanella S., Kumar N.N., Shi Y., Bevengut M., Penton D., Guyenet P.G., Lesage F., Gestreau C., Barhanin J. and Bayliss D.A. (2013). TASK-2 Channels Contribute to pH Sensitivity of Retrotrapezoid Nucleus Chemoreceptor Neurons.
J Neurosci, 33 (41) : 16033-16044
107 Stebe S., Schellig K., Lesage F., Breer H. and Fleischer J. (2014). The Thermosensitive Potassium Channel TREK-1 Contributes to Coolness-Evoked Responses of Grueneberg Ganglion Neurons.
Cell Mol Neurobiol, 34 (1) : 113-22
106 Chatelain F.C., Mazzuca M., Larroque M.M., Rogemond V., Honnorat J. and Lesage F. (2013). An ion channel chip for diagnosis and prognosis of autoimmune neurological disorders.
Recent Pat CNS Drug Discov, 8 (3) : 171-9
105 Bandulik S., Tauber P., Penton D., Schweda F., Tegtmeier I., Sterner C., Lalli E., Lesage F., Hartmann M., Barhanin J. and Warth R. (2013). Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.
Endocrinology, 154 (8) : 2712-22
104 Sandoz G. and Levitz J. (2013). Optogenetic techniques for the study of native potassium channels.
Front Mol Neurosci, 6 () : 6
103 Hao J., Padilla F., Dandonneau M., Lavebratt C., Lesage F., Noel J. and Delmas P. (2013). Kv1.1 channels act as mechanical brake in the senses of touch and pain.
Neuron, 77 (5) : 899-914
102 Sandoz G. and Isacoff E.Y. (2012). [Optical remote control of native ion channels].
Med Sci (Paris), 28 (11) : 934-7
101 Mirkovic K., Palmersheim J., Lesage F. and Wickman K. (2012). Behavioral characterization of mice lacking Trek channels.
Front Behav Neurosci, 6 () : 60
100 Tadmouri A., Kiyonaka S., Barbado M., Rousset M., Fablet K., Sawamura S., Bahembera E., Pernet-Gallay K., Arnoult C., Miki T., Sadoul K., Gory-Faure S., Lambrecht C., Lesage F., Akiyama S., Khochbin S., Baulande S., Janssens V., Andrieux A., Dolmetsch R., Ronjat M., Mori Y. and De Waard M. (2012). Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.
EMBO J, 31 (18) : 3730-44
99 Penton D., Bandulik S., Schweda F., Haubs S., Tauber P., Reichold M., Cong L.D., El Wakil A., Budde T., Lesage F., Lalli E., Zennaro M.C., Warth R. and Barhanin J. (2012). Task3 potassium channel gene invalidation causes low Renin and salt-sensitive arterial hypertension.
Endocrinology, 153 (10) : 4740-8
98 Peyronnet R., Sharif-Naeini R., Folgering J.H., Arhatte M., Jodar M., El Boustany C., Gallian C., Tauc M., Duranton C., Rubera I., Lesage F., Pei Y., Peters D.J., Somlo S., Sachs F., Patel A., Honore E. and Duprat F. (2012). Mechanoprotection by Polycystins against Apoptosis Is Mediated through the Opening of Stretch-Activated K(2P) Channels.
Cell Rep, 1 (3) : 241-50
97 Sandoz G., Levitz J., Kramer R.H. and Isacoff E.Y. (2012). Optical Control of Endogenous Proteins with a Photoswitchable Conditional Subunit Reveals a Role for TREK1 in GABA(B) Signaling.
Neuron, 74 (6) : 1005-14
96 Moha Ou Maati H., Borsotto M., Chatelain F., Widmann C., Lazdunski M. and Heurteaux C. (2012). Activation of ATP-sensitive potassium channels as an element of the neuroprotective effects of the Traditional Chinese Medicine MLC901 against oxygen glucose deprivation.
Neuropharmacology, 63 (4) : 692-700
95 Chatelain FC., Bichet D., Douguet D., Feliciangeli S., Bendahhou S., Reichold M., Warth R., Barhanin J. and Lesage F. (2012). TWIK1, a unique background channel with variable ion selectivity.
Proc Natl Acad Sci U S A, 109 (14) : 5499-5504
94 Lesage F. and Barhanin J. (2011). Molecular physiology of pH-sensitive background K2P channels.
Physiology, 26 (6) : 424-437
93 Noël J., Sandoz G. and Lesage F. (2011). Molecular regulations governing TREK and TRAAK functions.
Channels, 5 (5) : 402-409
92 Janovjak H., Sandoz G. and Isacoff E.Y. (2011). A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence.
Nat Commun, 2 () : 232
91 Sandoz G., Bell S.C. and Isacoff E.Y. (2011). Optical probing of a dynamic membrane interaction that regulates the TREK1 channel.
Proc Natl Acad Sci U S A, 108 (6) : 2605-10
90 Gestreau C., Heitzmann D., Thomas J., Dubreuil V., Bandulik S., Reichold M., Bendahhou S., Pierson P., Sterner C., Peyronnet-Roux J., Benfriha C., Tegtmeier I., Ehnes H., Georgieff M., Lesage F., Brunet JF., Goridis C., Warth R. and Barhanin J. (2010). Task2 potassium channels set central respiratory CO2 and O2 sensitivity
Proc Natl Acad Sci U S A, 107 (5) : 2325-2330
89 Feliciangeli S., Tardy MP., Sandoz G.,Chatelain F., Warth R., Barhanin J., Bendahhou S. and Lesage F. (2010). Potassium channel silencing by constitutive endocytosis and intracellular sequestration
J Biol Chem, 285 (7) : 4798-4805
88 Chatelain F.C., Gazzarrini S., Fujiwara Y., Arrigoni C., Domigan C., Ferrara G., Pantoja C., Thiel G., Moroni A. and Minor DL J.r. (2009). Selection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine block.
PLoS One, 4 (10) : e7496
87 Sandoz G., Douguet D., Chatelain F., Lazdunski M. and Lesage F. (2009). Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue
Proc Natl Acad Sci U S A, 106 (34) : 146268-14633
86 Burdakov D. and Lesage F. (2010). Glucose-induced inhibition: how many ionic mechanisms?
Acta Physiol (Oxf)., 198 (3) : 295-301
85 Guyon A., Tardy MP., Rovère C., Nahon JL., Barhanin J. and Lesage F. (2009). Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels
J Neurosci. , 29 (8) : 2528-2533
84 Sandoz G. and lesage F. (2008). Protein complex analysis of native brain potassium channels by proteomics
Methods Mol Biol, 491 () : 113-123
83 Sandoz G., Tardy M., Thummler S., Feliciangeli S., Lazdunski M. and lesage F. (2008). Mtap2 is a constituent of the protein network that regulates TREK channel expression and trafficking
J Neurosci , 28 (34) : 8545-8545
82 Heitzmann D., Derand R., Jungbauer S., Bandulik S., Sterner C., Schweda F., El Wakil A., Lalli E., Guy N., Mengual R., Reichold M., Tegtmeier I., Bendahhou S., Gomez-Sanchez C.E., Aller M.I., Wisden W., Weber A., Lesage F., Warth R. and Barhanin J. (2008). Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis
EMBO J, 27 (1) : 179-87
81 Feliciangeli S., Bendahhou S., Sandoz G., Gounon P., Reichold M., Warth R., Lazdunski M., Barhanin J. and Lesage F. (2007). Does Sumoylation Control K2P1/TWIK1 Background K+ Channels?
Cell, 130 (3) : 563-9
80 Mazzuca M. and Lesage F. (2007). Potassium channels, genetic and acquired diseases.
Rev Med Interne, 28 (8) : 576-579
79 Sandoz G., Thummler S., Duprat F., Feliciangeli S., Vinh J., Escoubas P., Guy N., Lazdunski M. and Lesage F. (2006). AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K+ channels into open leak channels
EMBO J, 25 (24) : 5864-72
78 Mazzuca M., Lesage F and Lazdunski M. (2006). Ion channels and epilepsy.
Epileptic Disord, 8 () : S1-16
77 Zanzouri M., Lauritzen I., Duprat F., Mazzuca M., Lesage F., Lazdunski M. and Patel A. (2006). Membrane potential-regulated transcription of the resting K+ conductance
J Biol Chem, 281 (39) : 28910-8
76 Goldstein S.A., Bayliss D.A., Kim D., Lesage F., Plant L.D. and Rajan S. (2005). International Union of Pharmacology. LV. Nomenclature and molecular
Pharmacol Rev, 57 (4) : 527-40
75 Ebensperger G., Ebensperger R., Herrera E.A., Riquelme R.A., Sanhueza E.M., Lesage F., Marengo J.J., Tejo R.I., Llanos A.J. and Reyes R.V. (2005). Fetal brain hypometabolism during prolonged hypoxaemia in the llama.
J Physiol, 567 (Pt 3) : 963-75
74 Mazzuca M., Lesage F. and Lazdunski M. (2004). Canaux ioniques et épilepsie.
Epileptic Disord, 6 (S1) : S1-16
73 Vamecq J., Vallee L., Lesage F., Gressens P. and Stables J.P. (2005). Antiepileptic popular ketogenic diet: emerging twists in an ancient story.
Prog Neurobiol, 75 (1) : 1-28
72 Decressac S., Franco M., Bendahhou S., Warth R., Knauer S., Barhanin J., Lazdunski M. and Lesage F. (2004). ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6
EMBO Rep, 5 (12) : 1171-5
71 Nicolas M.T., Lesage F., Reyes R., Barhanin J. and Dememes D. (2004). Localization of TREK-1, a two-pore-domain K+ channel in the peripheral
Brain Res, 1017 (1-2) : 46-52
70 Girard C. and Lesage F. (2004). Neuronal background two-P-domain potassium channels: molecular and
Med Sci (Paris), 20 (5) : 544-9
69 Warth R., Barriere H., Meneton P., Bloch M., Thomas J., Tauc M., Heitzmann D., Romeo E., Verrey F., Mengual R., Guy N., Bendahhou S., Lesage F., Poujeol P. and Barhanin J. (2004). Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals
Proc Natl Acad Sci U S A, 101 (21) : 8215-20
68 Lesage F., Hibino H. and Hudspeth A.J. (2004). Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels
Proc Natl Acad Sci U S A, 101 (2) : 671-5
67 Gutman G.A., Chandy K.G., Adelman J.P., Aiyar J., Bayliss D.A., Clapham D.E., Covarriubias M., Desir G.V., Furuichi K., Ganetzky B., Garcia M.L., Grissmer S., Jan L.Y., Karschin A., Kim D., Kuperschmidt S., Kurachi Y., Lazdunski M., Lesage F., Lester H.A., McKinnon D., Nichols C.G., O'Kelly I., Robbins J., Robertson G.A., Rudy B., Sanguinetti M., Seino S., Stuehmer W., Tamkun M.M., Vandenberg C.A., Wei A., Wulff H. and Wymore R.S. (2003). International Union of Pharmacology. XLI. Compendium of voltage-gated ion
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66 Chemin J., Girard C., Duprat F., Lesage F., Romey G. and Lazdunski M. (2003). Mechanisms underlying excitatory effects of group I metabotropic glutamate
EMBO J, 22 (20) : 5403-11
65 Barriere H., Belfodil R., Rubera I., Tauc M., Lesage F., Poujeol C., Guy N., Barhanin J. and Poujeol P. (2003). Role of TASK2 potassium channels regarding volume regulation in primary
J Gen Physiol, 122 (2) : 177-90
64 Magloire H., Lesage F., Couble M.L., Lazdunski M. and Bleicher F. (2003). Expression and localization of TREK-1 K+ channels in human odontoblasts.
J Dent Res, 82 (7) : 542-5
63 Lesage F. (2003). Pharmacology of neuronal background potassium channels.
Neuropharmacology, 44 (1) : 1-7
62 Hibino H., Pironkova R., Onwumere O., Rousset M., Charnet P., Hudspeth A.J. and Lesage F. (2003). Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit
Proc Natl Acad Sci U S A, 100 (1) : 307-12
61 Hibino H., Pironkova R., Onwumere O., Vologodskaia M., Hudspeth A.J. and Lesage F. (2002). RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels
Neuron, 34 (3) : 411-23
60 Terrenoire C., Lauritzen I., Lesage F., Romey G. and Lazdunski M. (2001). A TREK-1-like potassium channel in atrial cells inhibited by
Circ Res, 89 (4) : 336-42
59 Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G., Lazdunski M. and Lesage F. (2001). Genomic and functional characteristics of novel human pancreatic 2P domain
Biochem Biophys Res Commun, 282 (1) : 249-56
58 Lesage F., Barhanin J. and Meneton P. (2000). Potassium transport: molecular and pathophysiological aspects.
Med Sci (Paris), 16 (5) : 663-72
57 Lesage F. and Lazdunski M. (2000). Molecular and functional properties of two-pore-domain potassium channels.
Am J Physiol Renal Physiol, 279 (5) : F793-801
56 Lesage F., Terrenoire C., Romey G. and Lazdunski M. (2000). Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple
J Biol Chem, 275 (37) : 28398-405
55 Czirjak G., Fischer T., Spat A., Lesage F. and Enyedi P. (2000). TASK (TWIK-related acid-sensitive K+ channel) is expressed in glomerulosa
Mol Endocrinol, 14 (6) : 863-74
54 Maingret F., Lauritzen I., Patel A.J., Heurteaux C., Reyes R., Lesage F., Lazdunski M. and Honore E. (2000). TREK-1 is a heat-activated background K(+) channel.
EMBO J, 19 (11) : 2483-91
53 Bearzatto B., Lesage F., Reyes R., Lazdunski M. and Laduron P.M. (2000). Axonal transport of TREK and TRAAK potassium channels in rat sciatic
Neuroreport, 11 (5) : 927-30
52 Duprat F., Lesage F., Patel A.J., Fink M., Romey G. and Lazdunski M. (2000). The neuroprotective agent riluzole activates the two P domain K(+)
Mol Pharmacol, 57 (5) : 906-12
51 Lesage F., Maingret F. and Lazdunski M. (2000). Cloning and expression of human TRAAK, a polyunsaturated fatty
FEBS Lett, 471 (2-3) : 137-40
50 Maingret F., Patel A.J., Lesage F., Lazdunski M. and Honore E. (2000). Lysophospholipids open the two-pore domain mechano-gated K(+) channels
J Biol Chem, 275 (14) : 10128-33
49 Reyes R., Lauritzen I., Lesage F., Ettaiche M., Fosset M. and Lazdunski M. (2000). Immunolocalization of the arachidonic acid and mechanosensitive baseline
Neuroscience, 95 (3) : 893-901
48 Meneton P., Lesage F. and Barhanin J. (1999). Potassium ATPases, channels, and transporters: an overview.
Semin Nephrol, 19 (5) : 438-57
47 Maingret F., Patel A.J., Lesage F., Lazdunski M. and Honore E. (1999). Mechano- or acid stimulation, two interactive modes of activation of the
J Biol Chem, 274 (38) : 26691-6
46 Lopez-Coronado J.M., Belles J.M., Lesage F., Serrano R. and Rodriguez P.L. (1999). A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity,
J Biol Chem, 274 (23) : 16034-9
45 Patel A.J., Honore E., Lesage F., Fink M., Romey G. and Lazdunski M. (1999). Inhalational anesthetics activate two-pore-domain background K+ channels.
Nat Neurosci, 2 (5) : 422-6
44 Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G. and Lazdunski M. (1999). Cloning of a new mouse two-P domain channel subunit and a human homologue
J Biol Chem, 274 (17) : 11751-60
43 Maingret F., Fosset M., Lesage F., Lazdunski M. and Honore E. (1999). TRAAK is a mammalian neuronal mechano-gated K+ channel.
J Biol Chem, 274 (3) : 1381-7
42 Cluzeaud F., Reyes R., Escoubet B., Fay M., Lazdunski M., Bonvalet J.P., Lesage F. and Farman N. (1998). Expression of TWIK-1, a novel weakly inward rectifying potassium channel
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41 Reyes R., Duprat F., Lesage F., Fink M., Salinas M., Farman N. and Lazdunski M. (1998). Cloning and expression of a novel pH-sensitive two pore domain K+ channel
J Biol Chem, 273 (47) : 30863-9
40 Lesage F. and Lazdunski M. (1998). Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3)
Genomics, 51 (3) : 478-9
39 Patel A.J., Honore E., Maingret F., Lesage F., Fink M., Duprat F. and Lazdunski M. (1998). A mammalian two pore domain mechano-gated S-like K+ channel.
EMBO J, 17 (15) : 4283-90
38 Fink M., Lesage F., Duprat F., Heurteaux C., Reyes R., Fosset M. and Lazdunski M. (1998). A neuronal two P domain K+ channel stimulated by arachidonic acid and
EMBO J, 17 (12) : 3297-308
37 Arrighi I., Lesage F., Scimeca J.C., Carle G.F. and Barhanin J. (1998). Structure, chromosome localization, and tissue distribution of the mouse
FEBS Lett, 425 (2) : 310-6
36 Duprat F., Lesage F., Fink M., Reyes R., Heurteaux C. and Lazdunski M. (1997). TASK, a human background K+ channel to sense external pH variations near
EMBO J, 16 (17) : 5464-71
35 Murer G., Adelbrecht C., Lauritzen I., Lesage F., Lazdunski M., Agid Y. and Raisman-Vozari R. (1997). An immunocytochemical study on the distribution of two G-protein-gated
Neuroscience, 80 (2) : 345-57
34 Adelbrecht C., Murer M.G., Lauritzen I., Lesage F., Ladzunski M., Agid Y. and Raisman-Vozari R. (1997). An immunocytochemical study of a G-protein-gated inward rectifier K+
Neuroreport, 8 (4) : 969-74
33 Lauritzen I., De Weille J., Adelbrecht C., Lesage F., Murer G., Raisman-Vozari R. and Lazdunski M. (1997). Comparative expression of the inward rectifier K+ channel GIRK2 in the
Brain Res, 753 (1) : 8-17
32 Lesage F., Lauritzen I., Duprat F., Reyes R., Fink M., Heurteaux C. and Lazdunski M. (1997). The structure, function and distribution of the mouse TWIK-1 K+ channel.
FEBS Lett, 402 (1) : 28-32
31 Fink M., Duprat F., Lesage F., Reyes R., Romey G., Heurteaux C. and Lazdunski M. (1996). Cloning, functional expression and brain localization of a novel
EMBO J, 15 (24) : 6854-62
30 Vetter D.E., Mann J.R., Wangemann P., Liu J., McLaughlin K.J., Lesage F., Marcus D.C., Lazdunski M., Heinemann S.F. and Barhanin J. (1996). Inner ear defects induced by null mutation of the isk gene.
Neuron, 17 (6) : 1251-64
29 Lesage F., Reyes R., Fink M., Duprat F., Guillemare E. and Lazdunski M. (1996). Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.
EMBO J, 15 (23) : 6400-7
28 Barhanin J., Lesage F., Guillemare E., Fink M., Lazdunski M. and Romey G. (1996). K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac
Nature, 384 (6604) : 78-80
27 Fink M., Duprat F., Lesage F., Heurteaux C., Romey G., Barhanin J. and Lazdunski M. (1996). A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK)
J Biol Chem, 271 (42) : 26341-8
26 Hugnot J.P., Salinas M., Lesage F., Guillemare E., de Weille J., Heurteaux C., Mattei M.G. and Lazdunski M. (1996). Kv8.1, a new neuronal potassium channel subunit with specific inhibitory
EMBO J, 15 (13) : 3322-31
25 Lesage F., Mattei M., Fink M., Barhanin J. and Lazdunski M. (1996). Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to
Genomics, 34 (1) : 153-5
24 Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G. and Barhanin J. (1996). A pH-sensitive yeast outward rectifier K+ channel with two pore domains
J Biol Chem, 271 (8) : 4183-7
23 Lesage F., Guillemare E., Fink M., Duprat F., Lazdunski M., Romey G. and Barhanin J. (1996). TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a
EMBO J, 15 (5) : 1004-11
22 Lesage F., Fink M., Barhanin J., Lazdunski M. and Mattei M.G. (1995). Assignment of human G-protein-coupled inward rectifier K+ channel homolog
Genomics, 29 (3) : 808-9
21 Fink M., Duprat F., Heurteaux C., Lesage F., Romey G., Barhanin J. and Lazdunski M. (1996). Dominant negative chimeras provide evidence for homo and heteromultimeric
FEBS Lett, 378 (1) : 64-8
20 Duprat F., Guillemare E., Romey G., Fink M., Lesage F., Lazdunski M. and Honore E. (1995). Susceptibility of cloned K+ channels to reactive oxygen species.
Proc Natl Acad Sci U S A, 92 (25) : 11796-800
19 Chevillard C., Attali B., Lesage F., Fontes M., Barhanin J., Lazdunski M. and Mattei M.G. (1993). Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in
Genomics, 15 (1) : 243-5
18 Attali B., Guillemare E., Lesage F., Honore E., Romey G., Lazdunski M. and Barhanin J. (1993). The protein IsK is a dual activator of K+ and Cl- channels.
Nature, 365 (6449) : 850-2
17 Attali B., Lesage F., Ziliani P., Guillemare E., Honore E., Waldmann R., Hugnot J.P., Mattei M.G., Lazdunski M. and Barhanin J. (1993). Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier
J Biol Chem, 268 (32) : 24283-9
16 Honore E., Barhanin J., Attali B., Lesage F. and Lazdunski M. (1994). External blockade of the major cardiac delayed-rectifier K+ channel
Proc Natl Acad Sci U S A, 91 (5) : 1937-41
15 Lesage F., Attali B., Lakey J., Honore E., Romey G., Faurobert E., Lazdunski M. and Barhanin J. (1993). Are Xenopus oocytes unique in displaying functional IsK channel
Receptors Channels, 1 (2) : 143-52
14 Honore E., Lesage F. and Romey G. (1994). Molecular biology of voltage-gated K+ channels in heart.
Fundam Clin Pharmacol, 8 (2) : 108-16
13 Lesage F., Hugnot J.P., Amri E.Z., Grimaldi P., Barhanin J. and Lazdunski M. (1994). Expression cloning in K+ transport defective yeast and distribution of
Nucleic Acids Res, 22 (18) : 3685-8
12 Lesage F., Duprat F., Fink M., Guillemare E., Coppola T., Lazdunski M. and Hugnot J.P. (1994). Cloning provides evidence for a family of inward rectifier and G-protein
FEBS Lett, 353 (1) : 37-42
11 Duprat F., Lesage F., Guillemare E., Fink M., Hugnot J.P., Bigay J., Lazdunski M., Romey G. and Barhanin J. (1995). Heterologous multimeric assembly is essential for K+ channel activity of
Biochem Biophys Res Commun, 212 (2) : 657-63
10 Honore E., Guillemare E., Lesage F., Barhanin J. and Lazdunski M. (1994). Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to
FEBS Lett, 348 (3) : 259-62
9 Lesage F., Guillemare E., Fink M., Duprat F., Heurteaux C., Fosset M., Romey G., Barhanin J. and Lazdunski M. (1995). Molecular properties of neuronal G-protein-activated inwardly rectifying
J Biol Chem, 270 (48) : 28660-7
8 Honore E., Attali B., Romey G., Heurteaux C., Ricard P., Lesage F., Lazdunski M. and Barhanin J. (1991). Cloning, expression, pharmacology and regulation of a delayed rectifier K+
EMBO J, 10 (10) : 2805-11
7 Attali B., Honore E., Lesage F., Lazdunski M. and Barhanin J. (1992). Regulation of a major cloned voltage-gated K+ channel from human T
FEBS Lett, 303 (2-3) : 229-32
6 Lesage F., Attali B., Lazdunski M. and Barhanin J. (1992). ISK, a slowly activating voltage-sensitive K+ channel. Characterization of
FEBS Lett, 301 (2) : 168-72
5 Lesage F., Attali B., Lazdunski M. and Barhanin J. (1992). Developmental expression of voltage-sensitive K+ channels in mouse
FEBS Lett, 310 (2) : 162-6
4 Honore E., Attali B., Romey G., Lesage F., Barhanin J. and Lazdunski M. (1992). Different types of K+ channel current are generated by different levels of
EMBO J, 11 (7) : 2465-71
3 Honore E., Attali B., Lesage F., Barhanin J. and Lazdunski M. (1992). Receptor-mediated regulation of IsK, a very slowly activating,
Biochem Biophys Res Commun, 184 (3) : 1135-41
2 Attali B., Romey G., Honore E., Schmid-Alliana A., Mattei M.G., Lesage F., Ricard P., Barhanin J. and Lazdunski M. (1992). Cloning, functional expression, and regulation of two K+ channels in human
J Biol Chem, 267 (12) : 8650-7
1 Guillemare E., Honore E., Pradier L., Lesage F., Schweitz H., Attali B., Barhanin J. and Lazdunski M. (1992). Effects of the level of mRNA expression on biophysical properties,
Biochemistry, 31 (49) : 12463-8